Anti-Estrogen Receptor 抗体 [ESR1/1935]
Anti-Estrogen Receptor antibody [ESR1/1935]
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(1 Publication)
Mouse Monoclonal Estrogen Receptor alpha antibody. Suitable for WB, Protein Array, IHC-P and reacts with Human, Recombinant full length protein - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ESR1.
別名を表示する
ESR, NR3A1, ESR1, Estrogen receptor, ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Receptor antibody [ESR1/1935] (AB237995)
Formalin-fixed, paraffin-embedded human Endometrial Carcinoma tissue stained for Estrogen Receptor using ab237995 at 2 μg/mL in immunohistochemical analysis.
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Receptor antibody [ESR1/1935] (AB237995)
Formalin-fixed, paraffin-embedded human Breast Carcinoma tissue stained for Estrogen Receptor using ab237995 at 2 μg/mL in immunohistochemical analysis.
- WB
Supplier Data
Western blot - Anti-Estrogen Receptor antibody [ESR1/1935] (AB237995)
All lanes:
Western blot - Anti-Estrogen Receptor antibody [ESR1/1935] (ab237995) at 1 µg/mL
All lanes:
MCF7 (human breast adenocarcinoma cell line) whole cell lysate
Predicted band size: 66 kDa
false
- Protein Array
Unknown
Protein Array - Anti-Estrogen Receptor antibody [ESR1/1935] (AB237995)
ab237995 was tested in protein array against over 19000 different full-length human proteins.
Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.
A MAb is specific to its intended target if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Reactivity data
出荷温度及び保存条件
製品の状態
精製方法
精製に関する特記事項
バッファー組成
出荷温度
短期保存期間
短期保存温度
長期保存温度
分注に関する情報
保管に関する情報
補足情報
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The Estrogen Receptor functions as a transcription factor that regulates gene expression when it binds to its ligand which is commonly estradiol. Upon binding 17 beta estradiol the receptor dimerizes and interacts with specific DNA sequences to influence transcription. It significantly regulates genes responsible for cell growth differentiation and reproductive functions. The estradiol chemical structure allows for specific interactions with ER altering the transcriptional regulation in a ligand-dependent manner. Though functioning mainly as a monomer ER can form heterodimers with other nuclear receptors affecting its biological role.
Pathways
The Estrogen Receptor is an important player in the genomic signaling pathway where it modulates the expression of numerous target genes by direct DNA binding. It also participates in the non-genomic signaling pathway where it involves the activation of second messengers and kinases. ER closely associates with important proteins such as coactivators and corepressors in these pathways. Estradiol chemical formula interactions facilitate molecular events involving ER-alpha to influence components of cell proliferation and survival.
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ターゲットの情報
文献 (1)
Recent publications for all applications. Explore the full list and refine your search
American journal of respiratory and critical care medicine 206:260-270 PubMed35550018
2022
Applications
Unspecified application
Species
Unspecified reactive species
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