AB190942

Anti-Estrogen Inducible Protein pS2 抗体

Name: Anti-Estrogen Inducible Protein pS2 抗体 (ab190942) | Abcam
Brand: Abcam Limited
SKU: AB190942
Price: 75000 JPY
Availability: InStock

Anti-Estrogen Inducible Protein pS2 antibody

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(2 Publications)

Rabbit Polyclonal Estrogen Inducible Protein pS2 antibody. Suitable for IHC-P, WB and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Mouse Tff1 aa 50 to C-terminus.

別名を表示する

Ps2, Tff1, Trefoil factor 1, Protein pS2

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Inducible Protein pS2 antibody (AB190942)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Inducible Protein pS2 antibody (AB190942)

Immunohistochemical analysis of paraffin-embedded Rat intestine tissue labeling Estrogen Inducible Protein pS2 with ab190942 at 1 μg/ml.

Supplier Data

Western blot - Anti-Estrogen Inducible Protein pS2 antibody (AB190942)

All lanes:

Western blot - Anti-Estrogen Inducible Protein pS2 antibody (ab190942) at 0.5 µg/mL

All lanes:

Rat stomach tissue lysate

Predicted band size: 9 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Rat

アプリケーション

WB, IHC-P

applications

免疫原

Synthetic Peptide within Mouse Tff1 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q08423

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Estrogen Inducible Protein pS2 also known as Trefoil Factor 1 (TFF1) is a small protein with a mass of about 6.6 kDa. It is mainly expressed in the mucosa of the stomach and other tissues responsive to estrogen. pS2 functions mechanically as part of the trefoil factor family known for its role in mucosal protection and repair. pS2 has a distinctive three-loop structure which is key to its interaction with other molecules and substrates in the cellular environment.

Biological function summary

This trefoil factor plays a significant role in the process of epithelial regeneration and maintaining gastrointestinal tract integrity. It is not known to be part of a complex but works through interaction with various growth factors and cytokines. Its expression is regulated by estrogen making pS2 significant in estrogen-responsive tissues. These interactions contribute to maintaining the stability of epithelial lining aiding in cellular migration and wound healing.

Pathways

PS2 influences cellular signaling involved in the gastric mucosal defense mainly interacting with the Epidermal Growth Factor (EGF) pathway. It modulates the pathway's effects on cell proliferation and migration. Its role is linked to the mitigation of tissue damage indicating a connection with other proteins like the EGF receptor contributing to the repair and defense mechanisms of epithelial tissues.

PS2 has gained attention in breast cancer research. Its expression correlates with hormone receptor-positive breast cancer making it a potential biomarker for the disease. Additionally aberrant expression levels of pS2 might relate to gastric cancer where it plays a role in tumor progression and response to therapy. pS2 is closely connected to estrogen receptor proteins which guide its involvement in these cancers influencing prognosis and treatment strategies.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.

See full target information Tff1

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 11:4516 PubMed32908137

2020

Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells' heterogeneity.

Applications

Unspecified application

Species

Unspecified reactive species

Yehuda Schlesinger,Oshri Yosefov-Levi,Dror Kolodkin-Gal,Roy Zvi Granit,Luriano Peters,Rachel Kalifa,Lei Xia,Abdelmajeed Nasereddin,Idit Shiff,Osher Amran,Yuval Nevo,Sharona Elgavish,Karine Atlan,Gideon Zamir,Oren Parnas

Nature communications 11:2032 PubMed32341344

2020

Immunoglobulin expression and the humoral immune response is regulated by the non-canonical poly(A) polymerase TENT5C.

Applications

Unspecified application

Species

Unspecified reactive species

Aleksandra Bilska,Monika Kusio-Kobiałka,Paweł S Krawczyk,Olga Gewartowska,Bartosz Tarkowski,Kamil Kobyłecki,Dominika Nowis,Jakub Golab,Jakub Gruchota,Ewa Borsuk,Andrzej Dziembowski,Seweryn Mroczek

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Estrogen Inducible Protein pS2 抗体

Anti-Estrogen Inducible Protein pS2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Inducible Protein pS2 antibody (AB190942)

Western blot - Anti-Estrogen Inducible Protein pS2 antibody (AB190942)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

代替製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

組合せ製品

Assay Kits

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (2)

Abcam product promise