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Anti-ErbB3 / HER3 抗体 [SGP1] (ab20162)

Submit a review Q&A (2)References (3)

Key features and details

  • Mouse monoclonal [SGP1] to ErbB3 / HER3
  • Suitable for: IP, Flow Cyt
  • Reacts with: Human
  • Isotype: IgG1

リコンビナント抗体で、ロット間での高い再現性を実現

Product image
Anti-ErbB3 / HER3 antibody [SP71] (ab93739)
  • 異なるロット間での安定した再現性
  • 容易なスケールアップ
  • 評価試験による特異性の確認済み
  • 倫理基準に準拠 - アニマル・フリーの生産

製品の概要

  • 製品名

    Anti-ErbB3 / HER3 antibody [SGP1]
    ErbB3 / HER3 一次抗体 製品一覧

  • 製品の詳細

    Mouse monoclonal [SGP1] to ErbB3 / HER3

  • 由来種

    Mouse

  • アプリケーション

    適用あり: IP, Flow Cytmore details

  • 種交差性

    交差種: Human
    交差が予測される動物種: Mouse, Rat, Chimpanzee

  • 免疫原

    Recombinant full length protein corresponding to Human ErbB3/ HER3. 'c-erb B3 protein from transfected human kidney fibroblasts purified by wheatgerm lectin affinity chromatography'

  • エピトープ

    Extracellular domain.

  • 特記事項

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

製品の特性

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab20162の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
IP
Use at an assay dependent concentration.
Flow Cyt
Use at an assay dependent concentration.

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
特記事項
IP
Use at an assay dependent concentration.
Flow Cyt
Use at an assay dependent concentration.

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能

    Binds and is activated by neuregulins and NTAK.

  • 組織特異性

    Epithelial tissues and brain.

  • 関連疾患

    Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.

  • 配列類似性

    Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
    Contains 1 protein kinase domain.

  • 発生段階

    Overexpressed in a subset of human mammary tumors.

  • ドメイン

    The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.

  • 翻訳後修飾

    Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.

  • 細胞内局在

    Secreted and Cell membrane.
  • Information by UniProt

  • 参照データベース

    see all

  • 別名

    • c erbB 3 antibody
    • c erbB3 antibody
    • Erb b2 receptor tyrosine kinase 3 antibody
    • ErbB 3 antibody
    • ERBB3 antibody
    • ERBB3 protein antibody
    • erbB3 S antibody
    • ERBB3_HUMAN antibody
    • Glial growth factor receptor antibody
    • HER 3 antibody
    • HER3 antibody
    • Human epidermal growth factor receptor 3 antibody
    • LCCS2 antibody
    • MDA BF 1 antibody
    • MGC88033 antibody
    • p180 ErbB3 antibody
    • p45 sErbB3 antibody
    • p85 sErbB3 antibody
    • proto-oncogene-like protein c ErbB 3 antibody
    • proto-oncogene-like protein c ErbB3 antibody
    • Proto-oncogene-like protein c-ErbB-3 antibody
    • Receptor tyrosine protein kinase erbB 3 antibody
    • Receptor tyrosine protein kinase erbB3 antibody
    • Receptor tyrosine-protein kinase erbB-3 antibody
    • Tyrosine kinase type cell surface receptor HER3 antibody
    • Tyrosine kinase-type cell surface receptor HER3 antibody
    • v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 antibody
    • v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antibody
    • v erb b2 erythroblastic leukemia viral oncogene homolog 3 antibody
    see all

参考文献 (3)

ab20162 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab20162 は 3 報の論文で使用されています。

  • Vollmann-Zwerenz A  et al. Multichromatic phenotyping of HER receptor coexpression in breast tumor tissue samples using flow cytometry--possibilities and limitations. Cytometry A 77:387-98 (2010). PubMed: 20151455
  • Srinivasan R  et al. Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types. J Pathol 185:236-45 (1998). PubMed: 9771476
  • Rajkumar T & Gullick WJ A monoclonal antibody to the human c-erbB3 protein stimulates the anchorage-independent growth of breast cancer cell lines. Br J Cancer 70:459-65 (1994). PubMed: 8080731

レビューと Q&A

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レビューを送る 質問を送る

1-2 of 2 Abreviews or Q&A

Question

Inquiry: Dear Abcam Do you possibly have the protein sequence of this antibody? Thank you in advance for any help

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Answer

Thank you for contacting us.

We unfortunately can not offer information other than already published on the datasheet. I am sorry I will not be more helpful with this antibody as we do not have the epitope information.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Free Rabbit monoclonal antibody with any purchase of a primary antibody, while stocks last! Quote “RABMAB-XBSMG” in your next primary antibody order. For more information, visit the following link: https://www.abcam.com/index.html?pageconfig=resource&rid=15447

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Question

At this moment I want to order an anti-HER3 antibody. In the past I used the SGP1 clone from your company (Anti-ErbB 3 antibody [SGP1] (ab20162)). I'm wondering what constituents the solution is composed of. From your site I understand that it is only composed of PBS and the antibody. Is this correct or does it also contain certain additives like for example sodium azide?  

Read More
Answer

Thank you for contacting us.

The buffer Ab20162 is composed of PBS with no additives such as sodium azide. We will always list the constituents of the buffer on our website when available.


I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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