AB9774

Anti-Endothelial Cell 抗体 [RECA-1]

Name: Anti-Endothelial Cell 抗体 [RECA-1] (ab9774) | Abcam
Brand: Abcam Limited
SKU: AB9774
Price: 65000 JPY
Availability: InStock
Rating: 5 (19 reviews)

Anti-Endothelial Cell antibody [RECA-1]

BOND RX™ Validated
詳細を見る

(19 Reviews)

(123 Publications)

Anti-Endothelial Cell antibody [RECA-1] (ab9774) is a mouse monoclonal antibody detecting Endothelial Cell in IHC-P. Suitable for Rat.

- Over 100 publications
- Trusted since 2002

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Endothelial Cell antibody [RECA-1] (AB9774)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Endothelial Cell antibody [RECA-1] (AB9774)

IHC image of Endothelial Cell staining in Rat brain FFPE section, performed on a BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution

for 20 mins. The section was then incubated with ab9774, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

RECA-1

アイソタイプ

IgG1

キャリアフリー

交差種

Rat

アプリケーション

IHC-P

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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製品の詳細

What is this antibody validated in?
Anti-Endothelial Cell antibody [RECA-1] (ab9774) is a mouse monoclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Rat samples.

Trusted by the scientific community
Anti-Endothelial Cell [RECA-1] (ab9774) was first used in a scientific publication in 2002 and has been cited over 100 times in peer-reviewed journals.

Reviewed by scientists
Anti-Endothelial Cell [RECA-1] (ab9774) has over 15 independent reviews from customers.

Other related products
We have a range of other formats of antibody clone [RECA-1] also available for your convenience: ab9774, Alexa Fluor® 488 - ab197727, Carrier free - ab264524

Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification

バッファー組成

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 6.97% L-Arginine

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Endothelial cells sometimes referred to as endothelium form the thin layer of approximately 1-2 µm thickness that lines the interior surface of blood vessels and lymphatic vessels. They possess a considerable array of roles mainly being a barrier between the vessel lumen and surrounding tissue and they regulate the passage of materials and the transit of white blood cells into and out of the bloodstream. Endothelial cells are widespread found in veins arteries capillaries and the heart. These cells express a variety of markers used to identify them and antibodies targeting endothelial markers are valuable tools in research and diagnostics.

Biological function summary

Endothelial cells maintain vascular tone and blood fluidity and they mediate angiogenesis which is the development of new blood vessels from pre-existing ones. They achieve these functions through the expression of adhesion molecules and growth factors. Endothelial cells contribute to the formation of a selective permeability barrier and respond to mechanical and chemical signals. They do not function alone; they are part of a larger vascular complex that includes smooth muscle cells and pericytes.

Pathways

Endothelial cells play key roles in the nitric oxide (NO) signaling and angiogenesis pathways. They produce nitric oxide a critical molecule for vasodilation and blood pressure regulation through the action of enzymes like endothelial nitric oxide synthase (eNOS). In the angiogenesis pathway endothelial cells interact with proteins like vascular endothelial growth factor (VEGF) which signals the proliferation and migration processes necessary for new blood vessel formation.

Endothelial dysfunction links to cardiovascular conditions like atherosclerosis and hypertension. Damage or alteration in endothelial cell function can lead to abnormal vascular behavior. Oxidative stress and inflammation often disrupt endothelial activity involving proteins such as E-selectin and intercellular adhesion molecule-1 (ICAM-1) contributing to disease progression. Understanding these associations highlights the importance of endothelial cell studies in addressing cardiovascular disorders.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information Endothelial Cell

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文献 (123)

Recent publications for all applications. Explore the full list and refine your search

Materials today. Bio 34:102172 PubMed40822932

2025

Neuroactive network tissue based on dual-factor neuroregenerative bioactive coating scaffolds and neural stem cells for spinal cord injury repair.

Applications

Unspecified application

Species

Unspecified reactive species

Tianyi Liu,Wenhao Zhu,Zheng Wan,Cong Fu,Xiaoyu Zhang,Wenzhong Li,Wenchen Li,Zhenxu Wu,Min Guo,Mengtuan Long,Feiyang Yang,Hongyu Chen,Xingcheng Yi,Honglei Wang,Peibiao Zhang,Haifeng Wang

Frontiers in cell and developmental biology 13:1577045 PubMed40677920

2025

Age-dependent integration of cortical progenitors transplanted at CSF-neurogenic niche interface.

Applications

Unspecified application

Species

Unspecified reactive species

Gretchen Greene,Nikorn Pothayee,Jahandar Jahanipour,Hyesoo Jie,Jung-Hwa Tao-Cheng,Emily Petrus,Dragan Maric,Alan P Koretsky

Journal of translational medicine 23:671 PubMed40528218

2025

Decoding hippocampal subfield and glial responses in ischemia using single-cell transcriptomics.

Applications

Unspecified application

Species

Unspecified reactive species

Donghee Kwak,Ji Hyun Park,Yun Hak Kim,Hong Il Yoo

Chemical science 16:12421-12438 PubMed40469767

2025

Ultra-high resolution magnetic resonance microscopy of gadolinium gold nanoparticle-labeled cells in the rat brain.

Applications

Unspecified application

Species

Unspecified reactive species

Alena Kisel,Minrui Luo,Matthew D Bailey,Harman Ghuman,Matthew Rotz,Vinícius P Campos,Marcelo A C Vieira,T Kevin Hitchens,Thomas J Meade,Michel Modo

CNS neuroscience & therapeutics 31:e70372 PubMed40237247

2025

Distribution of Intranasally Administered rIL-10 Along the Olfactory Nerve and Perivascular Space After Intracerebral Hemorrhage.

Applications

Unspecified application

Species

Unspecified reactive species

Shaoshuai Wang,Junmin Wang,Xinru Zhang,Shijun Xu,Qinfeng Peng,Yifei Li,Ruoqi Ding,Bing Jiang,Shuyu Wang,Shuaibing Zhang,Siyuan Hu,Yousef Rastegar-Kashkooli,Na Xing,Nan Li,Menglu Wang,Junyang Wang,Xuemei Chen,Chao Jiang,Xiaochong Fan,Jian Wang

Theranostics 15:3837-3861 PubMed40213674

2025

Neural-enhancing PRP/Alg/GelMA triple-network hydrogel for neurogenesis and angiogenesis after spinal cord injury via PI3K/AKT/mTOR signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zhihe Yun,Jiuping Wu,Xinzhi Sun,Tao Yu,Wu Xue,Anyuan Dai,Tianyang Yuan,Xuhao Yang,Inbo Han,Yanting Liu,Wenlong Song,Qinyi Liu

Scientific reports 15:965 PubMed39762398

2025

Role of P × receptor during focused ultrasound induced blood brain barrier modulation.

Applications

Unspecified application

Species

Unspecified reactive species

Junwon Park,Young Cheol Na,Jihyeon Lee,Younghee Seo,Hojin Kim,Sangheon Han,Byeong-Wook Song,Won Seok Chang

Nature protocols 19:3542-3567 PubMed39075308

2024

Host circuit engagement of human cortical organoids transplanted in rodents.

Applications

Unspecified application

Species

Unspecified reactive species

Kevin W Kelley,Omer Revah,Felicity Gore,Konstantin Kaganovsky,Xiaoyu Chen,Karl Deisseroth,Sergiu P Pașca

Stroke and vascular neurology 10: PubMed38906547

2024

New rat model of spinal cord infarction with long-lasting functional disabilities generated by intraspinal injection of endothelin-1.

Applications

Unspecified application

Species

Unspecified reactive species

Masayuki Otani,Yoshihiro Kushida,Yasumasa Kuroda,Shohei Wakao,Yo Oguma,Keisuke Sasaki,Shintaro Katahira,Ryohei Terai,Rie Ryoke,Hiroi Nonaka,Ryuta Kawashima,Yoshikatsu Saiki,Mari Dezawa

Journal of the American Heart Association 13:e032533 PubMed38240234

2024

Interleukin 17A Contributes to Blood-Brain Barrier Disruption of Hypothalamic Paraventricular Nucleus in Rats With Myocardial Infarction.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Yu,Robert M Weiss,Shun-Guang Wei

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Endothelial Cell 抗体 [RECA-1]

Anti-Endothelial Cell antibody [RECA-1]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Endothelial Cell antibody [RECA-1] (AB9774)

関連する標識済み抗体及び組成の異なる製品 (2)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (123)

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Abcam product promise