Anti-ELK1 (phospho S383) 抗体
Anti-ELK1 (phospho S383) antibody
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(6 Publications)
Rabbit Polyclonal ELK1 phospho S383 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human ELK1 pS383 aa 350-450 conjugated to Keyhole Limpet Haemocyanin.
別名を表示する
ETS domain-containing protein Elk-1, ELK1
- IHC-P
Supplier Data
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELK1 (phospho S383) antibody (AB218133)
Immunohistochemical analysis of formalin-fixed paraffin-embedded Human lung carcinoma tissue, labeling ELK1 (phospho S383) using ab218133 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.
- WB
Supplier Data
Western blot - Anti-ELK1 (phospho S383) antibody (AB218133)
All lanes:
Western blot - Anti-ELK1 (phospho S383) antibody (ab218133) at 1/300 dilution
All lanes:
mouse brain lysates
Predicted band size: 45 kDa
true
Reactivity data
出荷温度及び保存条件
製品の状態
精製方法
バッファー組成
出荷温度
短期保存期間
短期保存温度
長期保存温度
分注に関する情報
保管に関する情報
補足情報
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ELK1 functions in the regulation of gene expression related to cellular proliferation and differentiation. It often forms a ternary complex with serum response factor (SRF) on serum response elements (SREs) to modulate the transcriptional responses of genes important for cell growth. The activation of ELK1 is phosphorylation-dependent primarily by mitogen-activated protein kinases (MAPKs) which further facilitates its role as a transcription regulator. This phosphorylation increases the transcriptional activity enabling ELK1 to actively participate in cellular responses to external signals.
Pathways
ELK1 participates prominently in the MAPK/ERK signaling pathway and the JNK signaling pathway. Through these pathways ELK1 gets activated influencing the transcription of immediate early genes responsible for cell cycle progression and apoptosis. ELK1 interacts with other proteins in these pathways such as MEK and ERK leading to a coordinated response to growth signals. These interactions underline its importance in signal transduction processes and cellular response mechanisms.
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文献 (6)
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Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 44:448-457 PubMed38767628
2024
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Unspecified application
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Unspecified reactive species
Cell proliferation 57:e13635 PubMed38594962
2024
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Unspecified reactive species
Marine drugs 21: PubMed37103364
2023
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Journal of cellular and molecular medicine 25:10724-10735 PubMed34704358
2021
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Unspecified reactive species
Communications biology 2:359 PubMed31602408
2019
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The Journal of biological chemistry 294:6871-6887 PubMed30824540
2019
Applications
Unspecified application
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Unspecified reactive species
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