Anti-EBV LMP2A 抗体 [15F9] (ab59028)
Key features and details
- Rat monoclonal [15F9] to EBV LMP2A
- Suitable for: WB, IHC-P
- Isotype: IgG1
製品の概要
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製品名
Anti-EBV LMP2A antibody [15F9] -
製品の詳細
Rat monoclonal [15F9] to EBV LMP2A -
由来種
Rat -
特異性
ab59028 recognises LMP2A and does not cross react with LMP2B. -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Epstein-Barr virus -
免疫原
Bacterial TrpE-LMP2A fusion protein
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ポジティブ･コントロール
- Hodgkin’s Disease
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
pH: 7.40
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Protein G purified -
特記事項（精製）
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant. -
ポリ/モノ
モノクローナル -
クローン名
15F9 -
ミエローマ
P3x63-Ag8.653 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab59028の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/100 - 1/1000.
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| IHC-P |
Use at an assay dependent dilution.
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| 特記事項 |
|---|
|
WB
1/100 - 1/1000. |
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IHC-P
Use at an assay dependent dilution. |
ターゲット情報
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関連性
Epstein Barr virus (EBV) is a member of the herpesvirus family and one of the most common human viruses. Most people become infected with EBV during their lives. Primary infections usually results in infectious mononucleosis (glandular fever) but the virus can also lay dormant in B lymphocytes and when reactivated become associated with more serious disease such as Burkitt's lymphoma, nasopharyngeal carcinoma and Hodgkin's disease. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals. -
参照データベース
- SwissProt: P13285 Epstein-Barr virus
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別名
- EBV latent membrane protein 2A antibody
- Epstein Barr virus antibody
- HHV4 antibody
see all
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (12)
ab59028 は 12 報の論文で使用されています。
- Liu W et al. Epstein-Barr Virus Regulates Endothelin-1 Expression through the ERK/FOXO1 Pathway in EBV-Associated Gastric Cancer. Microbiol Spectr 11:e0089822 (2023). PubMed: 36475746
- Xu M et al. Establishment and characterization of two Epstein-Barr virus-positive gastric cancer cell lines with epitheliotropic M81 strain undergoing distinct viral and altered cellular expression profiles. J Med Virol 95:e28387 (2023). PubMed: 36478267
- Guo R et al. Methionine metabolism controls the B cell EBV epigenome and viral latency. Cell Metab 34:1280-1297.e9 (2022). PubMed: 36070681
- Granai M et al. Immune landscape in Burkitt lymphoma reveals M2-macrophage polarization and correlation between PD-L1 expression and non-canonical EBV latency program. Infect Agent Cancer 15:28 (2020). PubMed: 32391073
- Guo R et al. DNA methylation enzymes and PRC1 restrict B-cell Epstein-Barr virus oncoprotein expression. Nat Microbiol 5:1051-1063 (2020). PubMed: 32424339