Anti-EBNA 3C 抗体 (ab16128)
Key features and details
- Sheep polyclonal to EBNA 3C
- Suitable for: ELISA, ICC/IF, IHC-Fr
- Isotype: IgG
製品の概要
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製品名
Anti-EBNA 3C antibody -
製品の詳細
Sheep polyclonal to EBNA 3C -
由来種
Sheep -
特異性
This antibody is specific for the Epstein Barr Virus Nuclear Antigen 3C. -
アプリケーション
適用あり: ELISA, ICC/IF, IHC-Frmore details -
種交差性
交差種: Epstein-Barr virus -
免疫原
Recombinant full length protein corresponding to Epstein-Barr virus EBNA 3C.
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特記事項
EBNA 3C is a latent viral nuclear protein expressed in EBV transformed lymphoblastic cell lines and is essential for EBV mediated transformation of these cell lines. This viral nuclear protein is essential for EBV mediated positive immunoblastic lymphomas, and functions as a transcription factor.
Source: Sheep were immunized with recombinant EBNA-3C protein
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.08% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Ammonium Sulphate Precipitation -
特記事項(精製)
Purified by ammonium sulfate precipitation This antibody is provided as a 0.2µm sterile filtered solution. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab16128の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ELISA |
Use at an assay dependent concentration.
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ICC/IF |
Use at an assay dependent concentration.
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IHC-Fr |
Use at an assay dependent concentration.
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特記事項 |
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ELISA
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. |
ターゲット情報
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関連性
EBNA 3C is a latent viral nuclear protein expressed in EBV transformed lymphoblastic cell lines and is essential for EBV mediated transformation of these cell lines. This viral nuclear protein is essential for EBV mediated positive immunoblastic lymphomas, and functions as a transcription factor. -
参照データベース
- SwissProt: P03204 Epstein-Barr virus
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別名
- EBNA 3C antibody
- EBNA 4B antibody
- EBNA 6 antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (9)
ab16128 は 9 報の論文で使用されています。
- Saikumar Lakshmi P et al. Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies. Life Sci Alliance 6:N/A (2023). PubMed: 36878637
- Gain C et al. Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway. PLoS Pathog 16:e1008105 (2020). PubMed: 32092124
- Wang LW et al. Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival. PLoS Pathog 15:e1008030 (2019). PubMed: 31518366
- Bhattacharjee S et al. Transcriptional and epigenetic modulation of autophagy promotes EBV oncoprotein EBNA3C induced B-cell survival. Cell Death Dis 9:605 (2018). PubMed: 29789559
- Gillman ACT et al. Epstein-Barr Virus Nuclear Antigen 3C Inhibits Expression of COBLL1 and the ADAM28-ADAMDEC1 Locus via Interaction with the Histone Lysine Demethylase KDM2B. J Virol 92:N/A (2018). PubMed: 30135119
- Siouda M et al. Epstein-Barr virus down-regulates tumor suppressor DOK1 expression. PLoS Pathog 10:e1004125 (2014). WB . PubMed: 24809689
- McClellan MJ et al. Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogramming. PLoS Pathog 9:e1003636 (2013). ChIP-sequencing . PubMed: 24068937
- McClellan MJ et al. Downregulation of Integrin Receptor-Signaling Genes by Epstein-Barr Virus EBNA 3C via Promoter-Proximal and -Distal Binding Elements. J Virol 86:5165-78 (2012). ChIP . PubMed: 22357270
- Sun X et al. Hsp90 inhibitors block outgrowth of EBV-infected malignant cells in vitro and in vivo through an EBNA1-dependent mechanism. Proc Natl Acad Sci U S A 107:3146-51 (2010). WB . PubMed: 20133771