Anti-E2F5 抗体 [220D1a] (ab59769)
![Western blot - Anti-E2F5 antibody [220D1a] (ab59769)](https://www.abcam.co.jp/ps/products/59/ab59769/Images/ab59769-73663-anti-e2f5-antibody-220d1a-western-blot.jpg "Western blot - Anti-E2F5 antibody [220D1a] (ab59769)")
Key features and details
- Mouse monoclonal [220D1a] to E2F5
- Suitable for: WB
- Isotype: IgG1
製品の概要
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製品名
Anti-E2F5 antibody [220D1a]
E2F5 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [220D1a] to E2F5 -
由来種
Mouse -
アプリケーション
適用あり: WBmore details -
免疫原
Recombinant fragment (Human)
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
pH: 7.40
Preservative: 0.05% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading... -
精製度
Protein G purified -
特記事項（精製）
Filtered through a 0.22 µm membrane. -
ポリ/モノ
モノクローナル -
クローン名
220D1a -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab59769の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use at an assay dependent concentration. Detects a band of approximately 38 kDa (predicted molecular weight: 38 kDa).
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| 特記事項 |
|---|
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WB
Use at an assay dependent concentration. Detects a band of approximately 38 kDa (predicted molecular weight: 38 kDa). |
ターゲット情報
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機能
Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. -
配列類似性
Belongs to the E2F/DP family. -
細胞内局在
Nucleus. - Information by UniProt
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別名
- E2F 5 antibody
- E2F transcription factor 5 antibody
- E2F transcription factor 5 p130 binding antibody
see all
画像
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Western blot - Anti-E2F5 antibody [220D1a] (ab59769)Anti-E2F5 antibody [220D1a] (ab59769) + immunizing peptide
Predicted band size: 38 kDa
Observed band size: 38 kDa
データシートおよび資料
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Datasheet download
参考文献 (7)
ab59769 は 7 報の論文で使用されています。
- Jiang G et al. hsa_circ_0084811 Regulates Cell Proliferation and Apoptosis in Retinoblastoma through miR-18a-5p/miR-18b-5p/E2F5 Axis. Biomed Res Int 2022:6918396 (2022). PubMed: 35909488
- Xie Y et al. CircFAM13B promotes the proliferation of hepatocellular carcinoma by sponging miR-212, upregulating E2F5 expression and activating the P53 pathway. Cancer Cell Int 21:410 (2021). PubMed: 34348712
- Sokolova V et al. The Effects of miR-20a on p21: Two Mechanisms Blocking Growth Arrest in TGF-β-Responsive Colon Carcinoma. J Cell Physiol 230:3105-14 (2015). PubMed: 26012475
- Wang L et al. A novel genetic system based on zinc finger nucleases for the identification of interactions between proteins in vivo. PLoS One 8:e85650 (2013). PubMed: 24392024
- Uboldi S et al. A systems biology approach to characterize the regulatory networks leading to trabectedin resistance in an in vitro model of myxoid liposarcoma. PLoS One 7:e35423 (2012). WB . PubMed: 22523595
- Jiang Y et al. A potential oncogenic role of the commonly observed E2F5 overexpression in hepatocellular carcinoma. World J Gastroenterol 17:470-7 (2011). WB, IHC-P ; Human . PubMed: 21274376
- Wan Z et al. Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors. J Clin Invest 120:3530-44 (2010). WB ; Human . PubMed: 20890043
