Anti-DRIP130 抗体 (ab70449)
Key features and details
- Rabbit polyclonal to DRIP130
- Suitable for: IP
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-DRIP130 antibody
DRIP130 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to DRIP130 -
由来種
Rabbit -
アプリケーション
適用あり: IPmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Horse, Guinea pig, Dog, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Orangutan, Zebra finch
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免疫原
Synthetic peptide, corresponding to a region between amino acids 400-450 of Human DRIP130 (SwissProt Q9ULK4)
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ポジティブ･コントロール
- Nuclear extract from HeLa cells
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7
Preservative: 0.09% Sodium azide
Constituents: 1.815% Tris, 1.764% Sodium citrate, 0.021% PBS -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab70449の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IP |
| 特記事項 |
|---|
Is unsuitable for WB.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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機能
Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. -
配列類似性
Belongs to the Mediator complex subunit 23 family. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 474822 Dog
- Entrez Gene: 9439 Human
- Entrez Gene: 70208 Mouse
- Omim: 605042 Human
- SwissProt: Q9ULK4 Human
- SwissProt: Q80YQ2 Mouse
- SwissProt: Q9CXY8 Mouse
- Unigene: 29679 Human
see all -
別名
- 130 kDa transcriptional co activator antibody
- 133 kDa transcriptional co activator antibody
- Activator recruited cofactor 130 kDa component antibody
see all
画像
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Immunoprecipitation - Anti-DRIP130 antibody (ab70449)Detection of Human DRIP130 by Immunoprecipitation in Nuclear extract (5 mg) from HeLa cells using ab70449 at 4 µg/5 mg extract. Detection: Coomassie stain.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab70449 は 1 報の論文で使用されています。
- Meyer KD et al. Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. EMBO J 27:1447-57 (2008). PubMed: 18418385