Anti-DREAM 抗体 (ab3474)
Key features and details
- Rabbit polyclonal to DREAM
- Suitable for: ICC/IF
- Reacts with: Rabbit
- Isotype: IgG
製品の概要
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製品名
Anti-DREAM antibody
DREAM 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to DREAM -
由来種
Rabbit -
特異性
Detects KChIP 3 from rabbit cerebellar granule cells. -
アプリケーション
適用あり: ICC/IFmore details -
種交差性
交差種: Rabbit
交差が予測される動物種: Mouse
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免疫原
Synthetic peptide corresponding to Mouse DREAM aa 30-45.
Sequence:IKWQRPRFTRQALMRC
(Peptide available asab5866) -
ポジティブ･コントロール
- ICC/IF: Rabbit granule cells
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 99% PBS -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab3474の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ICC/IF |
Use at an assay dependent concentration.
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| 特記事項 |
|---|
|
ICC/IF
Use at an assay dependent concentration. |
ターゲット情報
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機能
Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception.
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.
May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation. -
組織特異性
Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease. -
配列類似性
Belongs to the recoverin family.
Contains 4 EF-hand domains. -
翻訳後修飾
Palmitoylated. Palmitoylation enhances association with the plasma membrane.
Proteolytically cleaved by caspase-3.
Phosphorylation at Ser-63 inhibits cleavage by CASP3. -
細胞内局在
Cytoplasm. Cell membrane. Endoplasmic reticulum. Golgi apparatus. Nucleus. Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 56461 Mouse
- SwissProt: Q9QXT8 Mouse
- Unigene: 315292 Mouse
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別名
- 4933407H12Rik antibody
- A type potassium channel modulatory protein 3 antibody
- A-type potassium channel modulatory protein 3 antibody
see all
画像
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Immunocytochemistry/ Immunofluorescence - Anti-DREAM antibody (ab3474)
Immunolocalization of DREAM in Rabbit granule cells using ab3474.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab3474 は 2 報の論文で使用されています。
- Liang Y et al. iTRAQ-based proteomic analysis discovers potential biomarkers of diffuse axonal injury in rats. Brain Res Bull 153:289-304 (2019). PubMed: 31539556
- Tian NX et al. KChIP3 N-Terminal 31-50 Fragment Mediates Its Association with TRPV1 and Alleviates Inflammatory Hyperalgesia in Rats. J Neurosci 38:1756-1773 (2018). PubMed: 29335353