JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB3474

Anti-DREAM 抗体

Anti-DREAM antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal DREAM antibody. Suitable for ICC/IF and reacts with Rabbit samples. Cited in 2 publications.

別名を表示する

Csen, Dream, Kchip3, Calsenilin, A-type potassium channel modulatory protein 3, DRE-antagonist modulator, Kv channel-interacting protein 3, DREAM, KChIP3

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-DREAM antibody (AB3474)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-DREAM antibody (AB3474)

Immunolocalization of DREAM in Rabbit granule cells using ab3474.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Rabbit

アプリケーション

ICC/IF

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特異性

Detects KChIP 3 from rabbit cerebellar granule cells.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rabbit": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
Preservative: 0.05% Sodium azide Constituents: PBS, 0.1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

DREAM also called Downstream Regulatory Element Antagonist Modulator is a calcium-binding protein with a molecular mass of about 29 kDa. It is expressed in various tissues but shows higher levels in the brain and heart. DREAM belongs to the neuronal calcium sensory (NCS) family and acts as a transcriptional repressor that binds to the downstream regulatory element (DRE) sites on DNA. Through its calcium-binding ability DREAM modulates gene expression by changing its conformation depending on intracellular calcium levels.
Biological function summary

Calcium-binding proteins influence multiple cellular processes and DREAM participates in calcium signaling pathways important for neuronal function and gene transcription regulation. As part of the complex interactions within the cell DREAM modulates the expression of target genes by interacting with DRE sequences. Its regulatory role extends to processes including synaptic plasticity neuronal excitability and long-term depression. DREAM's function as a modulator of transcription links it to a broader regulatory network within cells.

Pathways

DREAM engages in calcium signaling pathways and is significant in the transcriptional regulation of genes involved in neuronal processes. DREAM interacts with CREB (cAMP response element-binding protein) and influences downstream gene expression in response to calcium fluctuations impacting the CREB signaling pathway. Additionally DREAM participates in pathways connected to the regulation of pain and inflammatory responses linking to proteins such as NF-kB which plays a role in immune response regulation.

Aberrations in DREAM function associate with neurodegenerative diseases and chronic pain conditions. Its regulatory role in neuronal gene expression connects DREAM to disorders like Alzheimer's and neuropathic pain. In these contexts altered DREAM activity can impact the expression of NF-kB and CREB target genes which are critical in mediating inflammatory responses and neuronal survival. Understanding DREAM's interactions and regulation could therefore provide insights into potential therapeutic targets for these conditions.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception.. Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.. May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation (By similarity).
See full target information Calsenilin
style
left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Brain research bulletin 153:289-304 PubMed31539556

2019

iTRAQ-based proteomic analysis discovers potential biomarkers of diffuse axonal injury in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Yue Liang,Fang Tong,Lin Zhang,Longlong Zhu,Wenhe Li,Weisheng Huang,Shuquan Zhao,Guanglong He,Yiwu Zhou

The Journal of neuroscience : the official journal 38:1756-1773 PubMed29335353

2018

KChIP3 N-Terminal 31-50 Fragment Mediates Its Association with TRPV1 and Alleviates Inflammatory Hyperalgesia in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Na-Xi Tian,Yu Xu,Jin-Yu Yang,Lu Li,Xiao-Hong Sun,Yun Wang,Ying Zhang
View all publications
style
left-column
style
left-column
style
right-column

代替製品

Primary Antibodies

AB61770

Anti-DREAM antibody

Immunocytochemistry/ Immunofluorescence - Anti-DREAM antibody (AB61770)

  • 4
  • 1

組合せ製品

Primary Antibodies

AB108309

Anti-CD1a antibody [EP3622]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD1a antibody [EP3622] (AB108309)

  • 0
  • 0
Primary Antibodies

AB64693

Anti-Mannose Receptor antibody

BOND RX™ Validated

Western blot - Anti-Mannose Receptor antibody (AB64693)

  • 5
  • 42
Primary Antibodies

AB108319

Anti-BDNF antibody [EPR1292]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Western blot - Anti-BDNF antibody [EPR1292] (AB108319)

  • 4
  • 9
Cell Lines & Lysates

AB94275

DREAM overexpression 293T lysate (whole cell)

Western blot - DREAM overexpression 293T lysate (whole cell) (AB94275)

  • 0
  • 0

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com