Anti-DR6 抗体 (ab8417)
Key features and details
- Rabbit polyclonal to DR6
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-DR6 antibody
DR6 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to DR6 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Human DR6 aa 42-56.
Sequence:QPEQKASNLIGTYRHC
(Peptide available asab8450) -
ポジティブ･コントロール
- WB: HeLa and K562 whole cell lysates.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
DEAE-Chromatography -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab8417の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/500 - 1/2000. Detects a band of approximately 68 kDa.
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| 特記事項 |
|---|
|
WB
1/500 - 1/2000. Detects a band of approximately 68 kDa. |
ターゲット情報
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機能
May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). -
組織特異性
Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. -
配列類似性
Contains 1 death domain.
Contains 4 TNFR-Cys repeats. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 27242 Human
- Omim: 605732 Human
- SwissProt: O75509 Human
- Unigene: 443577 Human
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別名
- TNFRSF 21 antibody
- BM 018 antibody
- BM018 antibody
see all
画像
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Western blot - Anti-DR6 antibody (ab8417)All lanes : Anti-DR6 antibody (ab8417) at 1/500 dilution
Lane 1 : K562 whole cell lysate with absence of blocking peptide
Lane 2 : Raji whole cell lysate with absence of blocking peptide
Lane 3 : K562 whole cell lysate with Human DR6 peptide (ab8450)
Lane 4 : Raji whole cell lysate with Human DR6 peptide (ab8450)
Observed band size: 68 kDa why is the actual band size different from the predicted?
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab8417 は 2 報の論文で使用されています。
- Zhang T et al. Amyloid precursor protein binds with TNFRSF21 to induce neural inflammation in Alzheimer's Disease. Eur J Pharm Sci 157:105598 (2021). PubMed: 33075465
- Klíma M et al. Functional analysis of the posttranslational modifications of the death receptor 6. Biochim Biophys Acta 1793:1579-87 (2009). WB ; Human . PubMed: 19654028