Anti-DR3/LARD 抗体 (ab8412)
Key features and details
- Rabbit polyclonal to DR3/LARD
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-DR3/LARD antibody
DR3/LARD 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to DR3/LARD -
由来種
Rabbit -
アプリケーション
適用あり: WB, ICC/IFmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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ポジティブ･コントロール
- Jurkat total cell lysate A 59 kDa band should be detected.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide -
Concentration information loading... -
精製度
Affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
軽鎖の種類
unknown -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab8412の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/500 - 1/1000. Detects a band of approximately 59 kDa.
|
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| ICC/IF | (1) |
Use a concentration of 10 µg/ml.
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| 特記事項 |
|---|
|
WB
1/500 - 1/1000. Detects a band of approximately 59 kDa. |
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ICC/IF
Use a concentration of 10 µg/ml. |
ターゲット情報
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機能
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. -
組織特異性
Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate. -
配列類似性
Contains 1 death domain.
Contains 4 TNFR-Cys repeats. -
翻訳後修飾
Glycosylated. -
細胞内局在
Secreted and Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 8718 Human
- Omim: 603366 Human
- SwissProt: Q93038 Human
- Unigene: 462529 Human
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別名
- Apo 3 antibody
- Apo-3 antibody
- Apo3 antibody
see all
画像
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Immunocytochemistry/ Immunofluorescence - Anti-DR3/LARD antibody (ab8412)
Immunocytochemistry/ Immunofluorescence of Jurkat cells staining DR3/LARD with ab8412 at 20 µg/ml
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Western blot - Anti-DR3/LARD antibody (ab8412)Anti-DR3/LARD antibody (ab8412) at 1/1000 dilution + Jurkat total cell lysate
Observed band size: 59 kDa why is the actual band size different from the predicted? -
Immunocytochemistry/ Immunofluorescence - Anti-DR3/LARD antibody (ab8412)ab8412 at 10µg/ml staining DR3/LARD in Jurkat cells by ICC/IF
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Immunocytochemistry/ Immunofluorescence - Anti-DR3/LARD antibody (ab8412)ab8412 at 20µg/ml staining DR3/LARD in Jurkat cells by ICC/IF
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab8412 は 3 報の論文で使用されています。
- Fu P et al. Aerobic exercise promotes the functions of brown adipose tissue in obese mice via a mechanism involving COX2 in the VEGF signaling pathway. Nutr Metab (Lond) 18:56 (2021). PubMed: 34082784
- Yang GL et al. TNFSF15 inhibits VEGF-stimulated vascular hyperpermeability by inducing VEGFR2 dephosphorylation. FASEB J 31:2001-2012 (2017). PubMed: 28183800
- Wang W et al. Involvement of TL1A and DR3 in induction of ischaemia and inflammation in urinary bladder dysfunction in the elderly. Mol Med Rep 6:434-8 (2012). PubMed: 22641456