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AB8412

Anti-DR3/LARD 抗体

Anti-DR3/LARD antibody

4

(4 Reviews)

|

(3 Publications)

Rabbit Polyclonal DR3/LARD antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications.

別名を表示する

APO3, DDR3, DR3, TNFRSF12, WSL, WSL1, UNQ455/PRO779, TNFRSF25, Tumor necrosis factor receptor superfamily member 25, Apo-3, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, Death receptor 3, Lymphocyte-associated receptor of death, Protein WSL, Protein WSL-1, LARD

4 Images
Immunocytochemistry/ Immunofluorescence - Anti-DR3/LARD antibody (AB8412)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-DR3/LARD antibody (AB8412)

ab8412 at 10µg/ml staining DR3/LARD in Jurkat cells by ICC/IF

Immunocytochemistry/ Immunofluorescence - Anti-DR3/LARD antibody (AB8412)
  • ICC/IF

Lab

Immunocytochemistry/ Immunofluorescence - Anti-DR3/LARD antibody (AB8412)

ab8412 at 20μg/ml staining DR3/LARD in Jurkat cells by ICC/IF

Immunocytochemistry/ Immunofluorescence - Anti-DR3/LARD antibody (AB8412)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-DR3/LARD antibody (AB8412)

Immunocytochemistry/ Immunofluorescence of Jurkat cells staining DR3/LARD with ab8412 at 20 μg/ml

Western blot - Anti-DR3/LARD antibody (AB8412)
  • WB

Unknown

Western blot - Anti-DR3/LARD antibody (AB8412)

All lanes:

Western blot - Anti-DR3/LARD antibody (ab8412) at 1/1000 dilution

All lanes:

Jurkat total cell lysate

Predicted band size: 45 kDa

Observed band size: 59 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

軽鎖のタイプ

unknown

キャリアフリー

No

交差種

Human

アプリケーション

ICC/IF, WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
+4°C
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The DR3 receptor also known as LARD (Lymphocyte Apoptosis-Related Receptor Domain) is a member of the TNF receptor superfamily. This protein also referred to as the DR3 protein or LARD protein is involved in mediating apoptotic signals. DR3 is expressed predominantly in lymphoid tissues and plays an important role in immune system regulation. DR3 protein has an approximate mass of 65 kDa. Scientists study DR3 in various models including cyno RNA and protein monkey models to gain better understanding of its function and expression.
Biological function summary

DR3 functions significantly in the immune response by modulating apoptosis. It forms part of a complex with other proteins leading to the activation of signaling pathways that result in cell death. The binding of its ligand TL1A to DR3 initiates a series of downstream effects that influence T-cell and other immune cell activities. LARD target has a functional correlation with the regulation of immune response and the maintenance of homeostasis in immune cell populations.

Pathways

DR3 receptor mediates signals primarily in two significant pathways: the NF-kB pathway and the MAPK pathway. These pathways play a role in transducing signals that lead to inflammation and immune responses. DR3 interacts with other proteins such as TRADD and RIPK1 facilitating the propagation of signals through these pathways. The engagement of DR3 in these pathways highlights its regulatory influence over immune cell survival and function.

DR3 plays an important role in autoimmune diseases and inflammatory disorders. Dysregulation of DR3 receptor and its signaling pathways can contribute to conditions like rheumatoid arthritis and inflammatory bowel disease. There is a notable connection between dysfunction in DR3 signaling and altered interactions with pro-inflammatory proteins such as TNF-alpha which can exacerbate these conditions. Understanding DR3's role helps in developing therapeutic approaches to manage these disorders.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
See full target information TNFRSF25
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Nutrition & metabolism 18:56 PubMed34082784

2021

Aerobic exercise promotes the functions of brown adipose tissue in obese mice via a mechanism involving COX2 in the VEGF signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Pengyu Fu,Rongxin Zhu,Jie Jia,Yang Hu,Chengjun Wu,Pawel Cieszczyk,Hans-Christer Holmberg,Lijing Gong

FASEB journal : official publication of the Federa 31:2001-2012 PubMed28183800

2017

TNFSF15 inhibits VEGF-stimulated vascular hyperpermeability by inducing VEGFR2 dephosphorylation.

Applications

Unspecified application

Species

Unspecified reactive species

Gui-Li Yang,Zilong Zhao,Ting-Ting Qin,Dong Wang,Lijuan Chen,Rong Xiang,Zhen Xi,Rongcai Jiang,Zhi-Song Zhang,Jianning Zhang,Lu-Yuan Li

Molecular medicine reports 6:434-8 PubMed22641456

2012

Involvement of TL1A and DR3 in induction of ischaemia and inflammation in urinary bladder dysfunction in the elderly.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Wang,Ning Zhang,Xu-Hui Zhu,Zhi-Song He,Wasilijiang Wahafu,Zhi-Qing Xu,Yong Yang
View all publications
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