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AB205039

Anti-DPYS 抗体

Anti-DPYS antibody

  • JP Hazardous:医薬用外毒物

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(1 Publication)

Rabbit Polyclonal DPYS antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DPYS aa 100-300.

別名を表示する

Dihydropyrimidinase, DHP, DHPase, Dihydropyrimidine amidohydrolase, Hydantoinase, DPYS

2 Images
Western blot - Anti-DPYS antibody (AB205039)
  • WB

Supplier Data

Western blot - Anti-DPYS antibody (AB205039)

All lanes:

Western blot - Anti-DPYS antibody (ab205039) at 1/500 dilution

All lanes:

human fetal liver lysate

Predicted band size: 57 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DPYS antibody (AB205039)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DPYS antibody (AB205039)

Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded human fetal pancreas tissue sections labeling DPYS with ab205039 at a 1/100 dilution.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P, WB

applications

免疫原

Recombinant Fragment Protein within Human DPYS aa 100-300. The exact immunogen used to generate this antibody is proprietary information.

Q14117

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Lyophilized
再構成
reconstitute with water at 200µL
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: 98% PBS, 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

DPYS also known as dihydropyrimidinase is an enzyme involved in the breakdown of pyrimidines specifically converting dihydropyrimidines to N-carbamyl-B-alanine. The mass of DPYS is approximately 56 kDa. This enzyme is present in various tissues most notably in the liver and kidney. DPYS plays a role in the catabolic pathway of nucleic acids facilitating the reuse and recycling of building blocks required for nucleic acid synthesis.
Biological function summary

DPYS functions as part of the larger pyrimidine degradation pathway. It does not act in isolation but may associate with other enzymes responsible for subsequent steps in this pathway. Pyrimidine metabolism is essential for maintaining the nucleotide pool balance in cells aiding cellular replication and repair processes. DPYS ensures efficient conversion of potentially harmful intermediates into products that cells can either reuse or excrete safely.

Pathways

The activity of DPYS is integrated into the pyrimidine catabolic pathway which intersects with the urea cycle. This enzyme works alongside others such as dihydropyrimidine dehydrogenase (DPYD) to facilitate pyrimidine degradation. The interactions between DPYS and DPYD are critical as they control the levels of pyrimidine metabolites in the cell preventing accumulation that could cause cellular stress or damage.

Mutations in the DPYS gene correlate with the rare metabolic disorder called dihydropyrimidinuria. This condition manifests due to the inefficient breakdown of pyrimidines leading to excessive urinary excretion of dihydropyrimidines. Furthermore impaired DPYS activity may have implications in drug metabolism particularly fluoropyrimidine-based cancer therapies as reduced activity can lead to toxicity. DPYD also connects to these conditions through its role in pyrimidine degradation highlighting the interdependence of these enzymes in both regular metabolic function and disease states.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
See full target information DPYS
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Drug metabolism and disposition: the biological fate of chemicals 51:165-173 PubMed36414408

2022

Functional Characterization of 12 Dihydropyrimidinase Allelic Variants in Japanese Individuals for the Prediction of 5-Fluorouracil Treatment-Related Toxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Eiji Hishinuma,Yoko Narita,Evelyn Marie Gutiérrez Rico,Akiko Ueda,Kai Obuchi,Yoshikazu Tanaka,Sakae Saito,Shu Tadaka,Kengo Kinoshita,Masamitsu Maekawa,Nariyasu Mano,Tomoki Nakayoshi,Akifumi Oda,Noriyasu Hirasawa,Masahiro Hiratsuka
View all publications
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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関連製品

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