Anti-Dopamine D2 Receptor 抗体 (ab85367)
Key features and details
- Rabbit polyclonal to Dopamine D2 Receptor
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
製品の概要
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製品名
Anti-Dopamine D2 Receptor antibody
Dopamine D2 Receptor 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Dopamine D2 Receptor -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Rat, Human
交差が予測される動物種: Chimpanzee, Monkey
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免疫原
Synthetic peptide corresponding to Human Dopamine D2 Receptor aa 1-100 conjugated to keyhole limpet haemocyanin.
(Peptide available asab97357) -
ポジティブ･コントロール
- This antibody gave a positive signal in the following tissue lysates: Human brain; Human skeletal muscle; Rat Substantia nigra; Rat Dopaminergic nucleus.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 1% BSA, 98.98% PBS
Batches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help. -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab85367の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 1 µg/ml. Detects a band of approximately 49 kDa (predicted molecular weight: 50 kDa).
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| 特記事項 |
|---|
|
WB
Use a concentration of 1 µg/ml. Detects a band of approximately 49 kDa (predicted molecular weight: 50 kDa). |
ターゲット情報
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機能
This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. -
関連疾患
Defects in DRD2 are associated with dystonia type 11 (DYT11) [MIM:159900]; also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. -
配列類似性
Belongs to the G-protein coupled receptor 1 family. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 1813 Human
- Entrez Gene: 13489 Mouse
- Entrez Gene: 24318 Rat
- Omim: 126450 Human
- SwissProt: P14416 Human
- SwissProt: P61168 Mouse
- SwissProt: P61169 Rat
- Unigene: 73893 Human
see all -
別名
- D(2) dopamine receptor antibody
- D2 dopamine receptor antibody
- D2DR antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (29)
ab85367 は 29 報の論文で使用されています。
- Li LF et al. Dopamine D2 receptors in the dorsomedial prefrontal cortex modulate social hierarchy in male mice. Curr Zool 69:682-693 (2023). PubMed: 37876636
- Hardy RE et al. The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors. Biol Direct 18:43 (2023). PubMed: 37528429
- Williams MT et al. Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model. PLoS One 17:e0274007 (2022). PubMed: 36112695
- Pitzer EM et al. Developmental deltamethrin: Sex-specific hippocampal effects in Sprague Dawley rats. Curr Res Toxicol 3:100093 (2022). PubMed: 36393872
- Hur KH et al. Methoxphenidine (MXP) induced abnormalities: Addictive and schizophrenia-related behaviours based on an imbalance of neurochemicals in the brain. Br J Pharmacol 178:3869-3887 (2021). PubMed: 33987827