Anti-DOPA Decarboxylase/DDC 抗体 (ab3905)
Key features and details
- Rabbit polyclonal to DOPA Decarboxylase/DDC
- Suitable for: WB
- Reacts with: Mouse, Rat
- Isotype: IgG
製品の概要
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製品名
Anti-DOPA Decarboxylase/DDC antibody
DOPA Decarboxylase/DDC 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to DOPA Decarboxylase/DDC -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Rat -
免疫原
Recombinant fragment corresponding to Bovine DOPA Decarboxylase/DDC. expressed in E. coli and purified from inclusion bodies
Database link: P27718 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.50
Preservative: 0.1% Sodium azide
Constituents: PBS, 0.316% Tris HCl, 0.05% Tween, 0.238% HEPES, 10% Glycerol, 0.1% BSA -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab3905の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (1) |
Use a concentration of 0.1 - 0.5 µg/ml.
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特記事項 |
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WB
Use a concentration of 0.1 - 0.5 µg/ml. |
ターゲット情報
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機能
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. -
パスウェイ
Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2. -
関連疾患
Defects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive. -
配列類似性
Belongs to the group II decarboxylase family. - Information by UniProt
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参照データベース
- Entrez Gene: 13195 Mouse
- Entrez Gene: 24311 Rat
- SwissProt: O88533 Mouse
- SwissProt: P14173 Rat
- Unigene: 12906 Mouse
- Unigene: 11064 Rat
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別名
- AADC antibody
- Aromatic L Amino Acid Decarboxylase antibody
- Aromatic-L-amino-acid decarboxylase antibody
see all
画像
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Anti-DOPA Decarboxylase/DDC antibody (ab3905) + Mouse cerebellum lysate at 0.2 mg/ml
Performed under reducing conditions. -
Anti-DOPA Decarboxylase/DDC antibody (ab3905) + Rat adrenal medulla lysate
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (34)
ab3905 は 34 報の論文で使用されています。
- Yang SH et al. Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice. Nat Commun 14:2435 (2023). PubMed: 37105975
- Troshev D et al. Compensatory Processes in Striatal Neurons Expressing the Tyrosine Hydroxylase Gene in Transgenic Mice in a Model of Parkinson's Disease. Int J Mol Sci 24:N/A (2023). PubMed: 38003434
- Seo DC et al. DDC-Promoter-Driven Chemogenetic Activation of SNpc Dopaminergic Neurons Alleviates Parkinsonian Motor Symptoms. Int J Mol Sci 24:N/A (2023). PubMed: 36768816
- Seebauer L et al. Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells. Int J Mol Sci 23:N/A (2022). PubMed: 35163733
- Sheng KY et al. A region-dependent allele-biased expression of Dopa decarboxylase in mouse brain. Front Cell Dev Biol 10:1078927 (2022). PubMed: 36568970