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AB3905

Anti-DOPA Decarboxylase/DDC 抗体

Anti-DOPA Decarboxylase/DDC antibody

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(9 Reviews)

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(39 Publications)

Rabbit Polyclonal DOPA Decarboxylase/DDC antibody. Suitable for WB and reacts with Mouse, Rat samples. Cited in 39 publications. Immunogen corresponding to Recombinant Fragment Protein within Cow DDC.

別名を表示する

Aromatic-L-amino-acid decarboxylase, AADC, DOPA decarboxylase, DDC

3 Images
Western blot - Anti-DOPA Decarboxylase/DDC antibody (AB3905)
  • WB

Supplier Data

Western blot - Anti-DOPA Decarboxylase/DDC antibody (AB3905)

All lanes:

Western blot - Anti-DOPA Decarboxylase/DDC antibody (ab3905)

All lanes:

Rat adrenal medulla lysate

Predicted band size: 53 kDa

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Western blot - Anti-DOPA Decarboxylase/DDC antibody (AB3905)
  • WB

Supplier Data

Western blot - Anti-DOPA Decarboxylase/DDC antibody (AB3905)

All lanes:

Western blot - Anti-DOPA Decarboxylase/DDC antibody (ab3905)

All lanes:

Mouse cerebellum lysate at 0.2 mg/mL

Predicted band size: 53 kDa

false

Western blot - Anti-DOPA Decarboxylase/DDC antibody (AB3905)
  • WB

CiteAb

Western blot - Anti-DOPA Decarboxylase/DDC antibody (AB3905)

DOPA Decarboxylase/DDC western blot using anti-DOPA Decarboxylase/DDC antibody ab3905. Publication image and figure legend from Chen, X., Lan, T., et al., 2020, Aging (Albany NY), PubMed 32074509.

ab3905 was used in this publication in western blot. This may not be the same as the application(s) guaranteed by Abcam. For a full list of applications guaranteed by Abcam for ab3905 please see the product overview.

Western blot analysis of protein expression levels of key enzymes and transporters in glutamatergic and monoaminergic pathways in the EC of mice after CRS exposure. β-actin and GAPDH were used to normalize the expression levels of proteins in control group and CRS group. (A) The protein expression levels of SERT, TH, AADC, MAOA and VMAT2 in monoaminergic pathway were examined by western blott (* p<0.05, n=6-7 mice per group). (B) The protein expression levels of GAD1, EAATT2, GLUL and SNAT1 in glutamatergic pathway were analyzed in both groups. (* p<0.05; n=6-7 mice per group).

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse, Rat

アプリケーション

WB

applications

免疫原

Recombinant Fragment Protein within Cow DDC. The exact immunogen used to generate this antibody is proprietary information.

P27718

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" } } }

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.5 Preservative: 0.1% Sodium azide Constituents: PBS, 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.238% HEPES, 0.1% BSA, 0.05% Sorbitan monolaurate, ethoxylated
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

DOPA Decarboxylase also known as DDC or aromatic L-amino acid decarboxylase is an enzyme critical in neurotransmitter production. It has a molecular mass of approximately 54 kDa. DOPA Decarboxylase converts L-DOPA to dopamine and 5-HTP to serotonin. This enzyme is expressed in tissues like the brain liver and kidney with high activity levels in the central nervous system.
Biological function summary

DOPA Decarboxylase plays an essential role in the synthesis of neurotransmitters such as dopamine and serotonin. It functions as part of the enzymatic conversion process and is not typically associated with larger complexes. The availability and activity of DDC directly influence the levels of these neurotransmitters affecting various physiological responses.

Pathways

DOPA Decarboxylase participates in the catecholamine biosynthesis pathway. This pathway is important for regulating body functions like mood motivation and fine motor control. DDC activity connects it with proteins such as tyrosine hydroxylase which provides the precursor L-DOPA for dopamine synthesis. Additionally it is involved in the serotonin biosynthesis pathway alongside tryptophan hydroxylase.

DOPA Decarboxylase shows significant relevance to conditions like Parkinson's disease and depression. Reduced DDC activity results in decreased dopamine levels which contribute to Parkinson’s symptoms. In depression altered DDC function affects serotonin levels. Its interaction with proteins like monoamine oxidase also plays a role in these disorders due to their involvement in neurotransmitter metabolism.

製品プロトコール

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ターゲットの情報

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin.
See full target information DDC

文献 (39)

Recent publications for all applications. Explore the full list and refine your search

Journal of biomedical science 32:78 PubMed40836335

2025

Smooth muscle-specific expression of hydroxyindole O-methyltransferase reduces arterial injury-induced intimal hyperplasia.

Applications

Unspecified application

Species

Unspecified reactive species

Wei-Cheng Jiang,Chung-Huang Chen,Hua-Hui Ho,Pei-Yu Gung,Jing-Yiing Wu,Cheng-Chin Kuo,Kenneth K Wu,Shaw-Fang Yet

International journal of molecular sciences 25: PubMed38279354

2024

Initial Molecular Mechanisms of the Pathogenesis of Parkinson's Disease in a Mouse Neurotoxic Model of the Earliest Preclinical Stage of This Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Kolacheva,Ekaterina Pavlova,Alyona Bannikova,Vsevolod Bogdanov,Michael Ugrumov

International journal of molecular sciences 24: PubMed38003434

2023

Compensatory Processes in Striatal Neurons Expressing the Tyrosine Hydroxylase Gene in Transgenic Mice in a Model of Parkinson's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Dmitry Troshev,Alyona Bannikova,Victor Blokhin,Ekaterina Pavlova,Anna Kolacheva,Michael Ugrumov

Nature communications 14:2435 PubMed37105975

2023

Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice.

Applications

Unspecified application

Species

Unspecified reactive species

Soo Hyun Yang,Esther Yang,Jaekwang Lee,Jin Yong Kim,Hyeijung Yoo,Hyung Sun Park,Jin Taek Jung,Dongmin Lee,Sungkun Chun,Yong Sang Jo,Gyeong Hee Pyeon,Jae-Yong Park,Hyun Woo Lee,Hyun Kim

International journal of molecular sciences 24: PubMed36768816

2023

DDC-Promoter-Driven Chemogenetic Activation of SNpc Dopaminergic Neurons Alleviates Parkinsonian Motor Symptoms.

Applications

Unspecified application

Species

Unspecified reactive species

Dong-Chan Seo,Yeon Ha Ju,Jin-Ju Seo,Soo-Jin Oh,C Justin Lee,Seung Eun Lee,Min-Ho Nam

Frontiers in cell and developmental biology 10:1078927 PubMed36568970

2022

A region-dependent allele-biased expression of Dopa decarboxylase in mouse brain.

Applications

Unspecified application

Species

Unspecified reactive species

Kit-Yeng Sheng,Toru Nakano,Shinpei Yamaguchi

International journal of molecular sciences 23: PubMed35163733

2022

Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Lukas Seebauer,Yanni Schneider,Alice Drobny,Sonja Plötz,Tomas Koudelka,Andreas Tholey,Iryna Prots,Beate Winner,Friederike Zunke,Jürgen Winkler,Wei Xiang

Frontiers in cell and developmental biology 9:676543 PubMed34239874

2021

Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart.

Applications

Unspecified application

Species

Unspecified reactive species

Adam R Prickett,Bertille Montibus,Nikolaos Barkas,Samuele M Amante,Maurício M Franco,Michael Cowley,William Puszyk,Matthew F Shannon,Melita D Irving,Marta Madon-Simon,Andrew Ward,Reiner Schulz,H Scott Baldwin,Rebecca J Oakey

Journal of neurochemistry 156:674-691 PubMed32730640

2020

Dopamine promotes the neurodegenerative potential of β-synuclein.

Applications

Unspecified application

Species

Unspecified reactive species

Anupam Raina,Kristian Leite,Sofia Guerin,Sameehan U Mahajani,Kalyan S Chakrabarti,Diana Voll,Stefan Becker,Christian Griesinger,Mathias Bähr,Sebastian Kügler

PLoS genetics 16:e1008868 PubMed32579581

2020

Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Chung-Yang Kao,Mafei Xu,Leiming Wang,Shih-Chieh Lin,Hui-Ju Lee,Lita Duraine,Hugo J Bellen,David S Goldstein,Sophia Y Tsai,Ming-Jer Tsai
View all publications

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