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AB54399

Anti-DNA helicase HEL308 抗体 [2406C1a]

Anti-DNA helicase HEL308 antibody [2406C1a]

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Mouse Monoclonal DNA helicase HEL308 antibody. Suitable for WB and reacts with Recombinant fragment samples. Immunogen corresponding to Recombinant Fragment Protein within Human HELQ.

別名を表示する

HEL308, HELQ, Helicase POLQ-like, Mus308-like helicase, POLQ-like helicase

1 Images
Western blot - Anti-DNA helicase HEL308 antibody [2406C1a] (AB54399)
  • WB

Unknown

Western blot - Anti-DNA helicase HEL308 antibody [2406C1a] (AB54399)

Western blot analysis of immunised recombinant protein fragment, using ab54399

All lanes:

Western blot - Anti-DNA helicase HEL308 antibody [2406C1a] (ab54399)

Predicted band size: 124 kDa

Observed band size: 40 kDa

false

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

2406C1a

アイソタイプ

IgG1

キャリアフリー

No

アプリケーション

WB

applications

免疫原

Recombinant Fragment Protein within Human HELQ. The exact immunogen used to generate this antibody is proprietary information.

Q8TDG4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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製品の詳細

ab54399 was filtered through a 0.22 µm membrane.
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
バッファー組成
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 1% BSA
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair (PubMed : 11751861, PubMed : 19995904, PubMed : 21398521, PubMed : 24005041, PubMed : 24005565, PubMed : 34316696, PubMed : 34937945). Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA) (PubMed : 34937945). Possesses both DNA unwinding and annealing activities (PubMed : 34937945). Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA (PubMed : 34937945). Efficiently unwinds substrates containing 3' overhangs or a D-loop (PubMed : 21398521, PubMed : 34937945). In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing (PubMed : 34937945). Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences (PubMed : 34316696, PubMed : 34937945).
See full target information HELQ
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Abcam product promise

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