AB2459

Anti-Dkk3 抗体

Name: Anti-Dkk3 抗体 (ab2459) | Abcam
Brand: Abcam Limited
SKU: AB2459
Price: 76000 JPY
Availability: InStock
Rating: 5 (3 reviews)

Anti-Dkk3 antibody

(3 Reviews)

(7 Publications)

Goat Polyclonal Dkk3 antibody. Suitable for WB and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human DKK3 aa 300 to C-terminus.

別名を表示する

REIC, UNQ258/PRO295, DKK3, Dickkopf-related protein 3, Dickkopf-3, Dkk-3, hDkk-3

1 Images

Supplier Data

Western blot - Anti-Dkk3 antibody (AB2459)

All lanes:

Western blot - Anti-Dkk3 antibody (ab2459) at 2 µg/mL

All lanes:

Human Cerebellum lysate at 35 µg

Predicted band size: 38 kDa

false

Key facts

宿主種

Goat

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

applications

免疫原

Synthetic Peptide within Human DKK3 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9UBP4

特異性

This antibody is expected to recognise the 350 aa isoform only.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.03-0.1 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

精製に関する特記事項

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

バッファー組成

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

See full target information DKK3

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文献 (7)

Recent publications for all applications. Explore the full list and refine your search

Theranostics 10:2553-2570 PubMed32194819

2020

HIF-1ɑ-regulated miR-1275 maintains stem cell-like phenotypes and promotes the progression of LUAD by simultaneously activating Wnt/β-catenin and Notch signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Neng Jiang,Chang Zou,Ying Zhu,Yifeng Luo,Lili Chen,Yiyan Lei,Kejing Tang,Yu Sun,Wenhui Zhang,Shuhua Li,Qiong He,Jianwen Zhou,Yangshan Chen,Jiping Luo,Wenting Jiang,Zunfu Ke

Scientific reports 9:19139 PubMed31844121

2019

LINC00459 sponging miR-218 to elevate DKK3 inhibits proliferation and invasion in melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yuhua Yang,Wenxian Xu,Zhuojun Zheng,Zhihai Cao

Nature communications 10:134 PubMed30635555

2019

Single-cell transcriptomic analysis of mouse neocortical development.

Applications

Unspecified application

Species

Unspecified reactive species

Lipin Loo,Jeremy M Simon,Lei Xing,Eric S McCoy,Jesse K Niehaus,Jiami Guo,E S Anton,Mark J Zylka

PloS one 11:e0154531 PubMed27140416

2016

Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq.

Applications

Species

Unspecified reactive species

S Marthandan,M Baumgart,S Priebe,M Groth,J Schaer,C Kaether,R Guthke,A Cellerino,M Platzer,S Diekmann,P Hemmerich

BioMed research international 2015:731938 PubMed26339636

2015

Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts.

Applications

Species

Unspecified reactive species

Shiva Marthandan,Steffen Priebe,Mario Baumgart,Marco Groth,Alessandro Cellerino,Reinhard Guthke,Peter Hemmerich,Stephan Diekmann

PloS one 9:e102559 PubMed25029272

2014

Pax6 regulates the expression of Dkk3 in murine and human cell lines, and altered responses to Wnt signaling are shown in FlpIn-3T3 cells stably expressing either the Pax6 or the Pax6(5a) isoform.

Applications

WB, WB, ICC/IF, ICC/IF

Species

Human, Mouse, Human, Mouse

Siri Forsdahl,Yury Kiselev,Rune Hogseth,Janne E Mjelle,Ingvild Mikkola

British journal of cancer 99:663-9 PubMed18665176

2008

MT1-MMP regulates urothelial cell invasion via transcriptional regulation of Dickkopf-3.

Applications

Species

Human

K Saeb-Parsy,A Veerakumarasivam,M J Wallard,N Thorne,Y Kawano,G Murphy,D E Neal,I G Mills,J D Kelly

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Dkk3 抗体

Anti-Dkk3 antibody

Western blot - Anti-Dkk3 antibody (AB2459)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

特異性

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

製品プロトコール

ターゲットの情報

文献 (7)

代替製品

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Primary Antibodies

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組合せ製品

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise