AB108221

Anti-Density Regulated Protein 抗体

Name: Anti-Density Regulated Protein 抗体 (ab108221) | Abcam
Brand: Abcam Limited
SKU: AB108221
Price: 74000 JPY
Availability: InStock

Anti-Density Regulated Protein antibody

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(2 Publications)

Rabbit Polyclonal Density Regulated Protein antibody. Suitable for WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human DENR aa 100 to C-terminus.

別名を表示する

DRP1, H14, DENR, Density-regulated protein, DRP, Protein DRP1, Smooth muscle cell-associated protein 3, SMAP-3

1 Images

Unknown

Western blot - Anti-Density Regulated Protein antibody (AB108221)

All lanes:

Western blot - Anti-Density Regulated Protein antibody (ab108221) at 0.1 µg/mL

Lane 1:

Hela whole cell lysate at 50 µg

Lane 2:

Hela whole cell lysate at 15 µg

Lane 3:

Hela whole cell lysate at 5 µg

Lane 4:

293T whole cell lysate at 50 µg

Lane 5:

NIH 3T3 whole cell lysate at 50 µg

Predicted band size: 22 kDa

true

Exposure time: 30s

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Mouse, Human

アプリケーション

applications

免疫原

Synthetic Peptide within Human DENR aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O43583

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Goat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Guinea pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Oncorhynchus mykiss": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Turkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Xenopus laevis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Xenopus tropicalis": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Density Regulated Protein also known as NDRG1 is integral to various cellular processes. It weighs approximately 43 kDa and is encoded by the NDRG1 gene. This protein is widely expressed in many tissues including the liver brain heart and skeletal muscle. NDRG1 shows a specific functional expression in cells undergoing differentiation and stress responses. Researchers have identified its connection with the regulation of cell growth and proliferation leading to its descriptive name.

Biological function summary

Density Regulated Protein plays an important role in cellular stress responses and differentiation regulation. This protein interacts with various signaling molecules indicating its participation in larger protein complexes. It modulates the cell cycle and is involved in response to hypoxia. It also plays a critical role in inhibiting metastasis showing its importance in maintaining normal cell behavior and suppressing abnormal growth.

Pathways

NDRG1 integrates prominently within the PI3K/AKT signaling pathway. This pathway is essential for regulation of cell survival metabolism and growth. Within this context the protein interacts with and influences other proteins such as PTEN and mTOR which are key components of the pathway. Moreover it cross-talks with other pathways such as TGF-beta further highlighting its multifaceted roles in cellular dynamics.

Density Regulated Protein is linked to several conditions notably cancer and neurodegenerative diseases. In cancer its expression levels are often altered correlating with tumor suppression and metastasis inhibition. The interaction with p53 a well-known tumor suppressor protein illustrates the significance of NDRG1 in oncology research. Additionally malfunctions of this protein can lead to inherited conditions such as Charcot-Marie-Tooth disease suggesting its essential role in neurological health and integrity.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Translation regulator forming a complex with MCTS1 to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent.

See full target information DENR

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

The EMBO journal 44:854-876 PubMed39748120

2025

MCTS2 and distinct eIF2D roles in uORF-dependent translation regulation revealed by in vitro re-initiation assays.

Applications

Unspecified application

Species

Unspecified reactive species

Romane Meurs,Mara De Matos,Adrian Bothe,Nicolas Guex,Tobias Weber,Aurelio A Teleman,Nenad Ban,David Gatfield

Nucleic acids research 47:5193-5209 PubMed30982898

2019

Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock.

Applications

Unspecified application

Species

Unspecified reactive species

Violeta Castelo-Szekely,Mara De Matos,Marina Tusup,Steve Pascolo,Jernej Ule,David Gatfield

View all publications

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Abcam product promise

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For licensing inquiries, please contact partnerships@abcam.com

Anti-Density Regulated Protein 抗体

Anti-Density Regulated Protein antibody

Western blot - Anti-Density Regulated Protein antibody (AB108221)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (2)

代替製品

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise