AB70215

Anti-DEFB-4 抗体

Name: Anti-DEFB-4 抗体 (ab70215) | Abcam
Brand: Abcam Limited
SKU: AB70215
Price: 78000 JPY
Availability: InStock

Anti-DEFB-4 antibody

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(2 Publications)

Rabbit Polyclonal DEFB-4 antibody. Suitable for WB, sELISA, I-ELISA, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human DEFB104A.

別名を表示する

DEFB104, DEFB4, DEFB104B, DEFB104A, Beta-defensin 104, Beta-defensin 4, BD-4, DEFB-4, hBD-4

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

sELISA, WB, ICC/IF, I-ELISA

applications

免疫原

Recombinant Full Length Protein corresponding to Human DEFB104A.

Q8WTQ1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"}, "IELISA" : {"fullname" : "Indirect ELISA", "shortname":"I-ELISA"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "Capture", "IELISA-species-checked": "guaranteed", "IELISA-species-dilution-info": "", "IELISA-species-notes": "Can be paired for ELISA with Rabbit polyclonal to DEFB-4 (Biotin) (<a href='/products/primary-antibodies/biotin-defb-4-antibody-ab70216'>ab70216</a>).", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Lyophilized

再構成

reconstitute with water at 0.5mg/mL

精製方法

Affinity purification Immunogen

バッファー組成

Constituents: PBS

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

DEFB-4 also known as beta-defensin 4 or human beta-defensin 2 (hBD-2) is a small antimicrobial peptide with a mass of about 4.5 kDa. This peptide belongs to the defensin family which plays a role in the immune response. DEFB-4 is expressed in epithelial cells including those in the skin respiratory tract and urogenital tract. It is induced by microbial presence and inflammatory cytokines such as IL-1 and TNF-alpha.

Biological function summary

This peptide exhibits antimicrobial activity against bacteria fungi and viruses. DEFB-4 disrupts microbial membranes leading to microbe death. It does not form part of a larger protein complex but it plays an important role in immune defense by recruiting and activating immune cells. It also exhibits chemotactic properties suggesting an involvement in modulating immune responses and interactions with other innate immune system components.

Pathways

DEFB-4 is involved in the innate immune pathway that mediates early responses to infections. Its interaction with the Toll-like receptor (TLR) pathways further enhances cytokine production. DEFB-4 acts alongside other beta-defensins like DEFB-1 contributing to a broader antimicrobial defensive network. Activation of these pathways results in coordinated immune responses that are critical during the early stages of microbial invasion.

The dysregulation of DEFB-4 expression associates with conditions such as psoriasis and cystic fibrosis. In psoriasis increased expression of DEFB-4 correlates with persistent inflammation and immune activity in the skin. In cystic fibrosis impaired DEFB-4 function can lead to an increased risk of chronic lung infections. The protein's relationship to IL-1 and TNF-alpha plays a role in these inflammatory conditions making DEFB-4 a target of interest for therapeutic research.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103.

See full target information DEFB104A

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of personalized medicine 14: PubMed39338219

2024

Characterization of Tissue Immunity Defense Factors of the Lip in Primary Dentition Children with Bilateral Cleft Lip Palate.

Applications

Unspecified application

Species

Unspecified reactive species

Laura Ozola,Mara Pilmane

Tobacco induced diseases 11:10 PubMed23627872

2013

Cigarette smoke extract induces differential expression levels of beta-defensin peptides in human alveolar epithelial cells.

Applications

ICC/IF

Species

Human

Tony Pierson,Sarah Learmonth-Pierson,Daniel Pinto,Monique L van Hoek

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-DEFB-4 抗体

Anti-DEFB-4 antibody

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

再構成

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (2)

代替製品

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise