Anti-Dectin-1 抗体 [GE2] - Low endotoxin, Azide free (ab82888)
Key features and details
- Mouse monoclonal [GE2] to Dectin-1 - Low endotoxin, Azide free
- Suitable for: Inhibition Assay, Flow Cyt
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-Dectin-1 antibody [GE2] - Low endotoxin, Azide free
Dectin-1 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [GE2] to Dectin-1 - Low endotoxin, Azide free -
由来種
Mouse -
特異性
Human beta Glucagon Receptor has two major (ßGR-A and ßGR-B) and several minor isoforms. ßGR-A and ßGR-B differ by the presence and absence, respectively, of a stalk region. ab82888 (clone GE2) recognizes both isoform A and B. -
アプリケーション
適用あり: Inhibition Assay, Flow Cytmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse
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免疫原
Tissue, cells or virus corresponding to Human Dectin-1. NIH/3T3 cells expressing full length Dectin-1.
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ポジティブ･コントロール
- Human peripheral blood monocytes
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.40
Constituent: PBS -
キャリア・フリー
はい -
Concentration information loading... -
精製度
Protein G purified -
特記事項（精製）
Endotoxin level: <0.01EU/ug -
ポリ/モノ
モノクローナル -
クローン名
GE2 -
ミエローマ
Sp2 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab82888の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Inhibition Assay |
Use at an assay dependent concentration.
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| Flow Cyt |
Use at an assay dependent concentration.
Use 10ul of the suggested working dilution to label 10^6 cells in 100ul. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
| 特記事項 |
|---|
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Inhibition Assay
Use at an assay dependent concentration. |
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Flow Cyt
Use at an assay dependent concentration. Use 10ul of the suggested working dilution to label 10^6 cells in 100ul. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
ターゲット情報
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機能
Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. -
組織特異性
Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta. -
関連疾患
Defects in CLEC7A may be a cause of familial candidiasis type 4 (CANDF4) [MIM:613108]. It is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. -
配列類似性
Contains 1 C-type lectin domain. -
翻訳後修飾
Phosphorylated on tyrosine residues in response to glucan binding. -
細胞内局在
Cytoplasm and Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 64581 Human
- Entrez Gene: 56644 Mouse
- Omim: 606264 Human
- SwissProt: Q9BXN2 Human
- SwissProt: Q6QLQ4 Mouse
- Unigene: 143929 Human
- Unigene: 239516 Mouse
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別名
- Beta GR antibody
- Beta-glucan receptor antibody
- BGR antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (9)
ab82888 は 9 報の論文で使用されています。
- Wang Y et al. Fungal dysbiosis of the gut microbiota is associated with colorectal cancer in Chinese patients. Am J Transl Res 13:11287-11301 (2021). PubMed: 34786058
- Keizer EM et al. EphA2-Dependent Internalization of A. fumigatus Conidia in A549 Lung Cells Is Modulated by DHN-Melanin. Front Microbiol 11:534118 (2020). PubMed: 33123097
- Camilli G et al. ß-Glucan-induced reprogramming of human macrophages inhibits NLRP3 inflammasome activation in cryopyrinopathies. J Clin Invest 130:4561-4573 (2020). PubMed: 32716363
- Camilli G et al. Impaired phagocytosis directs human monocyte activation in response to fungal derived ß-glucan particles. Eur J Immunol 48:757-770 (2018). PubMed: 29313961
- Xiao Y et al. Targeting CBLB as a potential therapeutic approach for disseminated candidiasis. Nat Med 22:906-14 (2016). PubMed: 27428899
- Bao Z et al. Evidence for the involvement of cofilin in Aspergillus fumigatus internalization into type II alveolar epithelial cells. BMC Microbiol 15:161 (2015). PubMed: 26268695
- Kyrmizi I et al. Corticosteroids block autophagy protein recruitment in Aspergillus fumigatus phagosomes via targeting dectin-1/Syk kinase signaling. J Immunol 191:1287-99 (2013). PubMed: 23817424
- Linden JR et al. The role of galectin-3 in phagocytosis of Candida albicans and Candida parapsilosis by human neutrophils. Cell Microbiol 15:1127-42 (2013). PubMed: 23279221
- Han X et al. ß-1,3-Glucan-Induced Host Phospholipase D Activation Is Involved in Aspergillus fumigatus Internalization into Type II Human Pneumocyte A549 Cells. PLoS One 6:e21468 (2011). Flow Cyt, Inhibition Assay ; Human . PubMed: 21760893
