AB108421

Anti-DcR2 抗体 [EPR3588(2)]

Anti-DcR2 antibody [EPR3588(2)]

BOND RX™ Validated
RabMAb
Recombinant
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(5 Publications)

Rabbit Recombinant Monoclonal DcR2 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications.

別名を表示する

CD264, DCR2, TRAILR4, TRUNDD, UNQ251/PRO288, TNFRSF10D, Tumor necrosis factor receptor superfamily member 10D, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TRAIL receptor with a truncated death domain, DcR2, TRAIL receptor 4, TRAIL-R4

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DcR2 antibody [EPR3588(2)] (AB108421)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DcR2 antibody [EPR3588(2)] (AB108421)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human thyroid carcinoma tissue sections labeling DcR2 with purified ab108421 at 1 : 8000 dilution (0.03 µg/ml). Heat mediated antigen retrieval was performed using Bond ™ Epitope Retrieval Solution 2 (pH 9.0). Rabbit specific IHC polymer detection kit HRP/DAB (ab209101) was used as the secondary antibody. Negative control : PBS instead of the primary antibody. Hematoxylin was used as a counterstain.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DcR2 antibody [EPR3588(2)] (AB108421)

Unpurified ab108421, at 1/250 dilution, staining DcR2 in paraffin-embedded Human kidney tissue by Immunohistochemistry.

Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DcR2 antibody [EPR3588(2)] (AB108421)

Unpurified ab108421, at 1/250 dilution, staining DcR2 in paraffin-embedded Human tonsil tissue by Immunohistochemistry.

Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Lab

Western blot - Anti-DcR2 antibody [EPR3588(2)] (AB108421)

The molecular weight observed is consistent with what has been described in PMID : 12865931

All lanes:

Western blot - Anti-DcR2 antibody [EPR3588(2)] (ab108421) at 1/1000 dilution

All lanes:

Human kidney lysates at 15 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/2000 dilution

Predicted band size: 42 kDa

Observed band size: 35 kDa

false

Unknown

Western blot - Anti-DcR2 antibody [EPR3588(2)] (AB108421)

All lanes:

Western blot - Anti-DcR2 antibody [EPR3588(2)] (ab108421) at 1/1000 dilution

Lane 1:

Fetal liver lysate at 10 µg

Lane 2:

Fetal kidney lysate at 10 µg

Lane 3:

Human prostate lysate at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 42 kDa

false

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR3588(2)

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

IHC-P, WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/8000", "IHCP-species-notes": "For unpurified use at 1/250 - 1/500. Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "" } } }

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製品の詳細

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

出荷温度

Conditional Ambient

短期保存温度

+4°C

長期保存温度

-20°C

保管に関する情報

Stable for 12 months at -20°C

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Receptor for the cytotoxic ligand TRAIL (PubMed : 9430226). Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis (PubMed : 9537512). Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed : 9382840, it cannot but according to PubMed : 9430226, it can induce the NF-kappa-B pathway (PubMed : 9382840, PubMed : 9430226).

See full target information TNFRSF10D

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular and molecular medicine 29:e70800 PubMed40845179

2025

Decoy Receptor 2 as a Cell Cycle Arrest Biomarker for Predicting Renal Recovery Following Acute Kidney Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Xiangling Yi,Liming Wang,Xiao-Yue Wang,Yu Fang,Jiarui Liu,Kehong Chen,Ya-Ni He,Jia Chen

Science translational medicine 14:eabj4375 PubMed36475903

2022

Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage.

Applications

Unspecified application

Species

Unspecified reactive species

Sofia Ferreira-Gonzalez,Tak Yung Man,Hannah Esser,Rhona Aird,Alastair M Kilpatrick,Daniel Rodrigo-Torres,Nicholas Younger,Lara Campana,Victoria L Gadd,Benjamin Dwyer,Niya Aleksieva,Luke Boulter,Mark T Macmillan,Yinmiao Wang,Katie J Mylonas,David A Ferenbach,Timothy J Kendall,Wei-Yu Lu,Juan Carlos Acosta,Dominic Kurian,Stephen O'Neill,Gabriel C Oniscu,Jesus M Banales,Paul J Krimpenfort,Stuart J Forbes

International journal of molecular sciences 23: PubMed36142828

2022

A Novel L-Phenylalanine Dipeptide Inhibits the Growth and Metastasis of Prostate Cancer Cells via Targeting DUSP1 and TNFSF9.

Applications

Unspecified application

Species

Unspecified reactive species

Lanlan Li,Mingfei Yang,Jia Yu,Sha Cheng,Mashaal Ahmad,Caihong Wu,Xinwei Wan,Bixue Xu,Yaacov Ben-David,Heng Luo

Cell death & disease 13:522 PubMed35661704

2022

Decoy receptor 2 mediates the apoptosis-resistant phenotype of senescent renal tubular cells and accelerates renal fibrosis in diabetic nephropathy.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Chen,Ke-Hong Chen,Li-Ming Wang,Jia Luo,Quan-You Zheng,Ya-Ni He

Science translational medicine 10: PubMed30111642

2018

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.

Applications

Unspecified application

Species

Unspecified reactive species

Thomas G Bird,Miryam Müller,Luke Boulter,David F Vincent,Rachel A Ridgway,Elena Lopez-Guadamillas,Wei-Yu Lu,Thomas Jamieson,Olivier Govaere,Andrew D Campbell,Sofía Ferreira-Gonzalez,Alicia M Cole,Trevor Hay,Kenneth J Simpson,William Clark,Ann Hedley,Mairi Clarke,Pauline Gentaz,Colin Nixon,Steven Bryce,Christos Kiourtis,Joep Sprangers,Robert J B Nibbs,Nico Van Rooijen,Laurent Bartholin,Steven R McGreal,Udayan Apte,Simon T Barry,John P Iredale,Alan R Clarke,Manuel Serrano,Tania A Roskams,Owen J Sansom,Stuart J Forbes

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-DcR2 抗体 [EPR3588(2)]

Anti-DcR2 antibody [EPR3588(2)]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DcR2 antibody [EPR3588(2)] (AB108421)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DcR2 antibody [EPR3588(2)] (AB108421)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DcR2 antibody [EPR3588(2)] (AB108421)

Western blot - Anti-DcR2 antibody [EPR3588(2)] (AB108421)

Western blot - Anti-DcR2 antibody [EPR3588(2)] (AB108421)

関連する標識済み抗体及び組成の異なる製品 (1)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

代替製品

Primary Antibodies

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

保管に関する情報

製品プロトコール

ターゲットの情報

文献 (5)

Abcam product promise