AB2087

Anti-DcR1 抗体

Anti-DcR1 antibody

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(6 Publications)

Rabbit Polyclonal DcR1 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human TNFRSF10C aa 100-150.

別名を表示する

CD263, DCR1, LIT, TRAILR3, TRID, UNQ321/PRO366, TNFRSF10C, Tumor necrosis factor receptor superfamily member 10C, Antagonist decoy receptor for TRAIL/Apo-2L, Decoy TRAIL receptor without death domain, Decoy receptor 1, Lymphocyte inhibitor of TRAIL, TNF-related apoptosis-inducing ligand receptor 3, TRAIL receptor without an intracellular domain, DcR1, TRAIL receptor 3, TRAIL-R3

3 Images

Immunocytochemistry/ Immunofluorescence - Anti-DcR1 antibody (AB2087)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-DcR1 antibody (AB2087)

Immunofluorescence of DcR1 in Rat Liver cells using ab2087 at 20 ug/ml.

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-DcR1 antibody (AB2087)

ab2087 at 10μg/ml staining DcR1 in rat liver tissue by ICC/IF

Unknown

Western blot - Anti-DcR1 antibody (AB2087)

Western blot analysis of DcR1 in HeLa cell (A), mouse (B) and rat (C) liver tissue lysates with anti-DcR1 (ED2) at 1 μg/ml.

All lanes:

Western blot - Anti-DcR1 antibody (ab2087) at 1 µg/mL

Lane 1:

Hela cell lysate

Lane 2:

Mouse liver tissue lysate

Lane 3:

Rat liver tissue lysate

Predicted band size: 27 kDa

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Mouse, Rat, Human

アプリケーション

WB, ICC/IF

applications

免疫原

Synthetic Peptide within Human TNFRSF10C aa 100-150. The exact immunogen used to generate this antibody is proprietary information.

O14798

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "Can be blocked with DcR1 peptide (human).", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "Can be blocked with DcR1 peptide (human).", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "Can be blocked with DcR1 peptide (human).", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "" } } }

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製品の詳細

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumour cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL (1-3). Two decoy-receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts were expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Ion exchange chromatography DEAE-C

バッファー組成

pH: 7.2 Preservative: 0.02% Sodium azide

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

See full target information TNFRSF10C

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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

Molecular neurobiology 57:3658-3670 PubMed32564286

2020

Ischemic Preconditioning Upregulates Decoy Receptors to Protect SH-SY5Y Cells from OGD Induced Cellular Damage by Inhibiting TRAIL Pathway and Agitating PI3K/Akt Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Jin,Wei Xu,Xiaoxiao Zhang,Chuan-Cheng Ren

Signal transduction and targeted therapy 5:40 PubMed32327638

2020

Enhancing the antitumor activity of an engineered TRAIL-coated oncolytic adenovirus for treating acute myeloid leukemia.

Applications

Unspecified application

Species

Unspecified reactive species

Zixuan Wang,Wenmo Liu,Lizheng Wang,Peng Gao,Zhe Li,Jiaxin Wu,Haihong Zhang,Hui Wu,Wei Kong,Bin Yu,Xianghui Yu

Molecular medicine reports 20:2812-2822 PubMed31322233

2019

The role of Zeb1 in the pathogenesis of morbidly adherent placenta.

Applications

Unspecified application

Species

Unspecified reactive species

Na Li,Tian Yang,Wenqian Yu,Hao Liu,Chong Qiao,Caixia Liu

Analytical biochemistry 583:113323 PubMed31129134

2019

Comparison of different label-free imaging high-throughput biosensing systems for aptamer binding measurements using thrombin aptamers.

Applications

Unspecified application

Species

Unspecified reactive species

Christin Rath,Juergen Burger,Leo Norval,Stefan Daniel Kraemer,Nicole Gensch,Alexander van der Kooi,Christine Reinemann,Ciara O'Sullivan,Marketa Svobodova,Guenter Roth

International journal of oncology 53:2258-2268 PubMed30132512

2018

β-catenin decreases acquired TRAIL resistance in non-small-cell lung cancer cells by regulating the redistribution of death receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Chengcheng You,Shimin Zhang,Yingming Sun,Shiyu Zhang,Guiliang Tang,Fang Tang,Xuefeng Liu,Yu Xiao,Junhong Zhang,Yan Gong,Conghua Xie

Gene therapy 17:550-9 PubMed20182517

2010

TRAIL gene-armed oncolytic poxvirus and oxaliplatin can work synergistically against colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

M F Ziauddin,Z S Guo,M E O'Malley,F Austin,P J Popovic,M A Kavanagh,J Li,M Sathaiah,P Thirunavukarasu,B Fang,Y J Lee,D L Bartlett

View all publications

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