Anti-Dact2 抗体 (ab79042)
Key features and details
- Rabbit polyclonal to Dact2
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Dact2 antibody -
製品の詳細
Rabbit polyclonal to Dact2 -
由来種
Rabbit -
アプリケーション
適用あり: WB, ICC/IFmore details -
種交差性
交差種: Human -
免疫原
A 12 amino acid synthetic peptide from near the amino terminus of human Dact2 (NP_999627).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab79042の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 83 kDa.
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| ICC/IF |
Use a concentration of 20 µg/ml.
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| 特記事項 |
|---|
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 83 kDa. |
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ICC/IF
Use a concentration of 20 µg/ml. |
ターゲット情報
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機能
Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors. -
配列類似性
Belongs to the dapper family. -
ドメイン
The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins. - Information by UniProt
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参照データベース
- Entrez Gene: 168002 Human
- Omim: 608966 Human
- SwissProt: Q5SW24 Human
- Unigene: 673059 Human
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別名
- bA503C24.7 antibody
- C6orf116 antibody
- Chromosome 6 open reading frame 116 antibody
see all
画像
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Western blot - Anti-Dact2 antibody (ab79042)Anti-Dact2 antibody (ab79042) at 1 µg/ml + SK N SH cell lysate at 15 µg
Predicted band size: 83 kDa
Observed band size: 83 kDa -
Immunocytochemistry/ Immunofluorescence - Anti-Dact2 antibody (ab79042)Immunofluorescence of Dact2 in Human Brain cells using ab79042 at 20 ug/ml.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab79042 は 4 報の論文で使用されています。
- Wang Y et al. miR-181a, delivered by hypoxic PTC-secreted exosomes, inhibits DACT2 by downregulating MLL3, leading to YAP-VEGF-mediated angiogenesis. Mol Ther Nucleic Acids 24:610-621 (2021). PubMed: 33898109
- Guo L et al. Methylation of DACT2 contributes to the progression of breast cancer through activating WNT signaling pathway. Oncol Lett 15:3287-3294 (2018). PubMed: 29435071
- Guo YL et al. Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma. J Biomed Sci 24:6 (2017). IHC-P ; Human . PubMed: 28077137
- Hou J et al. DACT2 is a candidate tumor suppressor and prognostic marker in esophageal squamous cell carcinoma. Cancer Prev Res (Phila) 6:791-800 (2013). PubMed: 23803417