Anti-Cytokeratin 5 + 14 抗体 [16.4] (ab16570)
Key features and details
- Mouse monoclonal [16.4] to Cytokeratin 5 + 14
- Suitable for: IHC-Fr, ICC/IF, WB
- Reacts with: Human
- Isotype: IgG2a
製品の概要
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製品名
Anti-Cytokeratin 5 + 14 antibody [16.4]
Cytokeratin 5 + 14 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [16.4] to Cytokeratin 5 + 14 -
由来種
Mouse -
アプリケーション
適用あり: IHC-Fr, ICC/IF, WBmore details -
種交差性
交差種: Human -
免疫原
This product was produced with the following immunogens:
Tissue, cells or virus corresponding to Cat Cytokeratin 5 + 14. cytokeratin enriched extract of feline tongue epithelium
Tissue, cells or virus corresponding to Mouse Cytokeratin 5 + 14. mouse myeloma cells -
特記事項
Cytokeratin proteins can be useful markers for tumor identification and classification. Belonging to the type A (acidic) subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.08% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Protein A/G purified -
ポリ/モノ
モノクローナル -
クローン名
16.4 -
アイソタイプ
IgG2a -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab16570の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-Fr |
Use at an assay dependent concentration.
|
|
| ICC/IF |
Use at an assay dependent concentration.
|
|
| WB |
Use at an assay dependent concentration.
|
| 特記事項 |
|---|
|
IHC-Fr
Use at an assay dependent concentration. |
|
ICC/IF
Use at an assay dependent concentration. |
|
WB
Use at an assay dependent concentration. |
ターゲット情報
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関連性
Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie., skin) and non keratinizing cells (i.e. mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. -
細胞内局在
Cytoplasmic; Basal layer -
参照データベース
- Entrez Gene: 3852 Human
- Entrez Gene: 3861 Human
- Omim: 148040 Human
- Omim: 148066 Human
- SwissProt: P02533 Human
- SwissProt: P13647 Human
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別名
- CK 14 antibody
- CK 5 antibody
- DDD antibody
see all
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (3)
ab16570 は 3 報の論文で使用されています。
- Arthur GK et al. KCa3.1 K+ Channel Expression and Function in Human Bronchial Epithelial Cells. PLoS One 10:e0145259 (2015). PubMed: 26689552
- Woodman LB et al. Synthetic response of stimulated respiratory epithelium: modulation by prednisolone and iKK2 inhibition. Chest 143:1656-66 (2013). ICC/IF ; Human . PubMed: 23238614
- Stenzinger A et al. Epidermal growth factor-, transforming growth factor-beta-, retinoic acid- and 1,25-dihydroxyvitamin D3-regulated expression of the novel protein PTPIP51 in keratinocytes. Cells Tissues Organs 184:76-87 (2006). PubMed: 17361080
