AB215904

Anti-Cytokeratin 18 抗体 [KRT18/834, KRT18/835, KRT18/836, KRT18/1190]

Name: Anti-Cytokeratin 18 抗体 [KRT18/834, KRT18/835, KRT18/836, KRT18/1190] (ab215904)
Brand: Abcam Limited
SKU: AB215904
Price: 74000 JPY
Availability: InStock

Anti-Cytokeratin 18 antibody [KRT18/834, KRT18/835, KRT18/836, KRT18/1190]

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(1 Publication)

Mouse Monoclonal Cytokeratin 18 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KRT18.

別名を表示する

CYK18, PIG46, KRT18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, Keratin-18, CK-18, K18

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 18 antibody [KRT18/834, KRT18/835, KRT18/836, KRT18/1190] (AB215904)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 18 antibody [KRT18/834, KRT18/835, KRT18/836, KRT18/1190] (AB215904)

Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human prostate carcinoma tissue labeling Cytokeratin 18 with ab215904 at 1 μg/ml dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 18 antibody [KRT18/834, KRT18/835, KRT18/836, KRT18/1190] (AB215904)

Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human thyroid carcinoma tissue labeling Cytokeratin 18 with ab215904 at 1 μg/ml dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 18 antibody [KRT18/834, KRT18/835, KRT18/836, KRT18/1190] (AB215904)

Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human colon carcinoma tissue labeling Cytokeratin 18 with ab215904 at 1 μg/ml dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 18 antibody [KRT18/834, KRT18/835, KRT18/836, KRT18/1190] (AB215904)

Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human cervical carcinoma tissue labeling Cytokeratin 18 with ab215904 at 1 μg/ml dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 18 antibody [KRT18/834, KRT18/835, KRT18/836, KRT18/1190] (AB215904)

Immunohistochemical analysis of formalin-fixed and paraffin-embedded Human lung carcinoma tissue labeling Cytokeratin 18 with ab215904 at 1 μg/ml dilution.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

KRT18/834, KRT18/835, KRT18/836, KRT18/1190

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

WB, IHC-P

applications

免疫原

Recombinant Full Length Protein corresponding to Human KRT18.

P05783

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代替製品

Primary Antibodies

AB206091

Alexa Fluor® 488 Anti-Cytokeratin 18 antibody [EPR1626]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 488 Anti-Cytokeratin 18 antibody [EPR1626] (AB206091)

Primary Antibodies

AB133302

Anti-Cytokeratin 18 antibody [EPR1611]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Cytokeratin 18 antibody [EPR1611] (AB133302)

Primary Antibodies

AB181597

Anti-Cytokeratin 18 antibody [EPR17347]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 18 antibody [EPR17347] (AB181597)

Primary Antibodies

AB133263

Anti-Cytokeratin 18 antibody [EPR1626]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 18 antibody [EPR1626] (AB133263)

Primary Antibodies

AB32118

Anti-Cytokeratin 18 antibody [E431-1]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 18 antibody [E431-1] (AB32118)

Primary Antibodies

AB194124

Alexa Fluor® 488 Anti-Cytokeratin 18 antibody [E431-1]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 488 Anti-Cytokeratin 18 antibody [E431-1] (AB194124)

組合せ製品

Assay Kits

AB227896

Human Cytokeratin 18 ELISA Kit

Recombinant|SimpleStep

ELISA - Human Cytokeratin 18 ELISA Kit (AB227896)

Primary Antibodies

AB53280

Anti-Cytokeratin 8 antibody [EP1628Y] - Cytoskeleton Marker

KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 8 antibody [EP1628Y] - Cytoskeleton Marker (AB53280)

Primary Antibodies

AB119695

Anti-Cytokeratin 14 antibody [SP53]

Immunocytochemistry/ Immunofluorescence - Anti-Cytokeratin 14 antibody [SP53] (AB119695)

Primary Antibodies

AB16667

Anti-Ki67 antibody [SP6]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

Primary Antibodies

AB52625

Anti-Cytokeratin 19 antibody [EP1580Y] - Cytoskeleton Marker

Multiplex immunohistochemistry - Anti-Cytokeratin 19 antibody [EP1580Y] - Cytoskeleton Marker (AB52625)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A/G

精製に関する特記事項

ab215904 is purified from Bioreactor Concentrate by Protein A/G.

バッファー組成

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Cytokeratin 18 (CK18) also known as Keratin 18 or KRT18 is a type I intermediate filament protein with a molecular weight of approximately 45 kDa. It plays a mechanical role in stabilizing epithelial cell structure and function. CK18 is expressed in single-layered epithelial tissues such as the liver intestine and pancreas. It partners with the type II keratin usually KRT8 to form a stable cytoskeletal network in these cells providing structural integrity and resilience.

Biological function summary

CK18 maintains cellular integrity and mediates resistance to mechanical and non-mechanical stresses in epithelial cells. It forms heterodimers with KRT8 participating in a complex network of filaments important for maintaining cell shape and stability. This organization plays a role in managing cell survival during stress and apoptosis helping regulate cellular functions and responses in tissues where it is expressed.

Pathways

Cytokeratin 18 is involved in the apoptosis and cellular stress response pathways. It interacts with proteins such as caspases during apoptosis facilitating cytoskeletal reorganization and cell fragmentation. CK18 in coordination with KRT8 also participates in signaling pathways that regulate cell cycle and apoptotic processes underlining its importance in cellular turnover and tissue homeostasis.

Elevated levels of CK18 fragments are often observed in cases of non-alcoholic steatohepatitis (NASH) and breast cancer. It serves as a biomarker for liver injury due to its abundance in hepatocytes and release upon cell death. In breast cancer alterations in CK18 expression can reflect disease progression where it interacts with other proteins such as vimentin indicating epithelial-to-mesenchymal transition a process that facilitates metastasis.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Required for the formation of KRT8/KRT18 filaments that are involved in ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement (PubMed : 26823019). Also acts downstream of ROCK kinase activation as part of a positive feedback mechanism in response to cellular mechanical stress loading (PubMed : 26823019). Organization and orientation of KRT18 filaments are responsible for the properly elongated morphology of epithelial tubules (By similarity). Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

See full target information KRT18

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Osteoarthritis and cartilage open 7:100649 PubMed40735537

2025

Comorbid hypertension and osteoarthritis exacerbates joint remodeling and gait compensations in female rats with milder effects observed in males.

Applications

Unspecified application

Species

Unspecified reactive species

Carlos J Cruz,Folly M Patterson,Janak Gaire,Julianna Gonzalez,Jacob L Griffith,Angela Philistin,Kyle D Allen

View all publications

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