JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB198870

Anti-Cytochrome P450 2B6/CYP2B6 抗体

Anti-Cytochrome P450 2B6/CYP2B6 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal Cytochrome P450 2B6/CYP2B6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Cytochrome P450 2B6.

別名を表示する

Cytochrome P450 2B6, CYPIIB6, Cytochrome P450 IIB1, CYP2B6

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytochrome P450 2B6/CYP2B6 antibody (AB198870)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytochrome P450 2B6/CYP2B6 antibody (AB198870)

Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue labeling Cytochrome P450 2B6/CYP2B6 with ab198870 at 1/25 dilution.

Western blot - Anti-Cytochrome P450 2B6/CYP2B6 antibody (AB198870)
  • WB

Supplier Data

Western blot - Anti-Cytochrome P450 2B6/CYP2B6 antibody (AB198870)

Gel : 8% SDS-PAGE

All lanes:

Western blot - Anti-Cytochrome P450 2B6/CYP2B6 antibody (ab198870) at 1/400 dilution

All lanes:

Human colon cancer tissue lysate at 40 µg

Predicted band size: 56 kDa

false

Exposure time: 4min

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, IHC-P

applications

免疫原

Synthetic Peptide within Human Cytochrome P450 2B6. The exact immunogen used to generate this antibody is proprietary information.

P20813

style
left-column

代替製品

Primary Antibodies

AB140609

Anti-Cytochrome P450 2B6/CYP2B6 antibody [EPR9985(B)]

RabMAb|Recombinant

Western blot - Anti-Cytochrome P450 2B6/CYP2B6 antibody [EPR9985(B)] (AB140609)

  • 1
  • 1

組合せ製品

Primary Antibodies

AB3572

Anti-Cytochrome P450 3A4/CYP3A4 antibody

Western blot - Anti-Cytochrome P450 3A4/CYP3A4 antibody (AB3572)

  • 0
  • 0
Primary Antibodies

AB22717

Anti-Cytochrome P450 1A2 antibody [d15 (16VII F10F12)]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytochrome P450 1A2 antibody [d15 (16VII F10F12)] (AB22717)

  • 4
  • 6
Primary Antibodies

AB137015

Anti-CYP2C19 antibody [EPR6576]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP2C19 antibody [EPR6576] (AB137015)

  • 0
  • 0
Assay Kits

AB65340

Creatinine Assay Kit

Biochemical assay - Creatinine Assay Kit (AB65340)

  • 5
  • 2
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Cytochrome P450 2B6 (CYP2B6) an essential enzyme in the cytochrome P450 superfamily plays a role in the metabolism of various substances. Often referred to as CYP2B6 or P450 2B6 this enzyme has a molecular mass of approximately 56 kDa. CYP2B6 is predominantly expressed in the liver but also found in the brain and testes. It catalyzes oxidation reactions thereby affecting the biotransformation of endogenous and exogenous compounds including drugs and steroids.
Biological function summary

CYP2B6 is involved in metabolizing drugs and synthesizing cholesterol steroids and other lipids. It forms part of a broader enzymatic complex that facilitates these biochemical reactions. As a monooxygenase it introduces an oxygen atom into its substrates contributing to drug metabolism and clearance from the body. This function aids detoxification processes and supports homeostasis.

Pathways

CYP2B6 is integral to the metabolism of xenobiotics and drug biotransformation pathways. It closely interacts with other cytochrome P450 enzymes such as CYP3A4 in these pathways. During drug metabolism these enzymes can affect the pharmacokinetics and pharmacodynamics of various pharmaceutical agents influencing their efficacy and toxicity.

CYP2B6 shows a connection with drug-induced liver injury and certain neurological disorders. Genetic polymorphisms in CYP2B6 can affect its function leading to variability in drug metabolism between individuals. This can contribute to adverse drug reactions or altered therapeutic effects. The enzyme's interaction with proteins like CYP2D6 relates to altered responses to antidepressants impacting treatment outcomes.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids (PubMed : 12865317, PubMed : 21289075). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed : 21289075). Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 (PubMed : 12865317, PubMed : 21289075). Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs (PubMed : 11695850, PubMed : 22909231). Acts as a 1,4-cineole 2-exo-monooxygenase (PubMed : 11695850).. Allele 2B6*9 : Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs.
See full target information Cytochrome P450 2B6
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Aging and disease 15:804-823 PubMed37611899

2023

Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency.

Applications

Unspecified application

Species

Unspecified reactive species

Feiyan Zhao,Long Yan,Xuehan Zhao,Jiaqi Wu,Ying Fang,Zhimin Xin,Hongmei Wang,Xiaokui Yang
View all publications
style
left-column
style
left-column
style
right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com