Anti-CYP21A2 抗体 (ab64887)
Key features and details
- Rabbit polyclonal to CYP21A2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-CYP21A2 antibody
CYP21A2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to CYP21A2 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide derived from an internal sequence of human CYP21A2.
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ポジティブ･コントロール
- extracts from 293 cells.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab64887の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/100 - 1/500. Detects a band of approximately 56, 40 kDa (predicted molecular weight: 56 kDa).
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| 特記事項 |
|---|
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WB
1/100 - 1/500. Detects a band of approximately 56, 40 kDa (predicted molecular weight: 56 kDa). |
ターゲット情報
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機能
Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. -
関連疾患
Adrenal hyperplasia 3 -
配列類似性
Belongs to the cytochrome P450 family. -
ドメイン
The leucine-rich hydrophobic amino acid N-terminal region probably helps to anchor the protein to the microsomal membrane. -
細胞内局在
Endoplasmic reticulum membrane. Microsome membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 1589 Human
- Omim: 613815 Human
- SwissProt: P08686 Human
- Unigene: 654479 Human
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別名
- CYP21 antibody
- 21 OHase antibody
- 21-OHase antibody
see all
画像
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Western blot - Anti-CYP21A2 antibody (ab64887)All lanes : Anti-CYP21A2 antibody (ab64887) at 1/500 dilution
Lane 1 : extracts from 293 cells (5-30µg total protein)
Lane 2 : extracts from 293 cells (5-30µg total protein) and 5-10µg of the immunising peptide.
Predicted band size: 56 kDa
Observed band size: 56 kDa
Additional bands at: 40 kDa. We are unsure as to the identity of these extra bands.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab64887 は 2 報の論文で使用されています。
- Bouhaddioui W et al. CYP21A2 expression is localized in the developing distal epithelium of the human perinatal lung and is compatible with in situ production and intracrine actions of active glucocorticoids. J Steroid Biochem Mol Biol 163:12-9 (2016). PubMed: 27004467
- Idkowiak J et al. Concomitant mutations in the P450 oxidoreductase and androgen receptor genes presenting with 46,XY disordered sex development and androgenization at adrenarche. J Clin Endocrinol Metab 95:3418-27 (2010). WB ; Human . PubMed: 20410220