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AB24982

Cy5 ® Anti-CD45.1 抗体 [A20]

Cy5 ® Anti-CD45.1 antibody [A20]

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(1 Publication)

Anti-CD45.1 antibody [A20] conjugated to Cy5® - suitable for flow cytometry, ICC/IF, IP, and reacts with mouse samples. Clone [A20] is a mouse monoclonal antibody and one of the most commonly used clones for flow cytometry.

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別名を表示する

CD45, Ly-5, Ptprc, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, Lymphocyte antigen 5, T200, L-CA

関連する標識済み抗体及び組成の異なる製品 (1)

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

A20

アイソタイプ

IgG2a

軽鎖のタイプ

kappa

標識

Cy5®

励起波長/蛍光波長

Ex: 650nm, Em: 667nm

キャリアフリー

No

交差種

Mouse

アプリケーション

Flow Cyt, IP, ICC/IF

applications

特異性

ab24982 recognizes all mouse leukocytes expressing the CD45.1 allotype.

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代替製品

Primary Antibodies

AB25348

APC Anti-CD45.1 antibody [A20]

Flow Cytometry - APC Anti-CD45.1 antibody [A20] (AB25348)

  • 0
  • 0
Primary Antibodies

AB24917

FITC Anti-CD45.1 antibody [A20]

  • 4
  • 1
Primary Antibodies

AB25011

Biotin Anti-CD45.1 antibody [A20]

  • 0
  • 0
Primary Antibodies

AB210237

PerCP/Cy5.5® Anti-CD45.1 antibody [A20]

Flow Cytometry - PerCP/Cy5.5® Anti-CD45.1 antibody [A20] (AB210237)

  • 0
  • 0

組合せ製品

Assay Kits

AB277445

Mouse CD45 ELISA kit

ELISA - Mouse CD45 ELISA kit (AB277445)

  • 0
  • 0
Primary Antibodies

AB307134

Alexa Fluor® 488 Anti-CD3 antibody [SP162]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 488 Anti-CD3 antibody [SP162] (AB307134)

  • 0
  • 0
Primary Antibodies

AB225310

Alexa Fluor® 647 Anti-CD4 antibody [EPR19514]

RabMAb|Recombinant

Immunohistochemistry (Frozen sections) - Alexa Fluor® 647 Anti-CD4 antibody [EPR19514] (AB225310)

  • 5
  • 1
Primary Antibodies

AB197701

Alexa Fluor® 488 Anti-CD11b antibody [M1/70]

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 488 Anti-CD11b antibody [M1/70] (AB197701)

  • 0
  • 0
Primary Antibodies

AB64693

Anti-CD206 antibody

BOND RX™ Validated

Western blot - Anti-CD206 antibody (AB64693)

  • 5
  • 42
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/products/unavailable/mouse-igg2a-lambda-monoclonal-hopc-1-cy5-isotype-control-ab154446'>ab154446</a> - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.</p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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製品の詳細

This product or portions thereof is manufactured under license from Carnegie Mellon University under U.S. Patent Number 5, 268, 486 and related patents. Cy® and CyDye® are trademarks of Cytiva.
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification
バッファー組成
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
+4°C
保管に関する情報
Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD45.1 also known as Leukocyte Common Antigen (LCA) or Protein Tyrosine Phosphatase Receptor Type C (PTPRC) is a protein expressed on the surface of all nucleated hematopoietic cells. It has a molecular mass of approximately 180-220 kDa. This protein acts as a receptor-type protein tyrosine phosphatase. CD45.1 is an essential marker in the immune system particularly found on T cells B cells and other white blood cells. The expression of CD45.1 is seen across leukocytes where it plays a significant role in cell signaling and antigen receptor signaling.
Biological function summary

CD45.1 influences the immune response by modulating signals through antigen receptors. It operates as a single-pass type I membrane protein and is not known to be part of a larger complex. This protein is important in the activation and regulation of T-cells and B-cells by fine-tuning the threshold of signals required for cell activation. The presence of CD45.1 affects multiple processes in adaptive immunity impacting lymphocyte development and their further activation in immune responses.

Pathways

CD45.1 is integral in lymphocyte activation pathways. It influences the T-cell receptor (TCR) and B-cell receptor (BCR) signaling pathways by dephosphorylating specific kinases like Lck and Fyn which are important in initiating TCR and BCR signaling cascades. Moreover CD45.1 interacts with other proteins such as CD3 and CD19 being essential in the regulation of immune response and maintaining proper signaling amplitudes to ensure effective immune function.

CD45.1 is intricately linked to autoimmune diseases and leukemia. The protein's dysregulation can lead to improper immune signaling contributing to conditions such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). In leukemia the altered expression of CD45.1 and related proteins such as CD20 often correlates with disease progression and treatment response. Understanding the roles of CD45.1 can facilitate the development of targeted therapies in these contexts.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity. Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity.
See full target information Ptprc
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Oncotarget 7:72486-72502 PubMed27732963

2016

RNA binding protein, tristetraprolin in a murine model of recurrent pregnancy loss.

Applications

Unspecified application

Species

Unspecified reactive species

Kasra Khalaj,Rayana Leal Luna,Maria Eduarda Rocha de França,Wilma Helena de Oliveira,Christina Alves Peixoto,Chandrakant Tayade
View all publications
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Abcam product promise

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