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AB228707

Anti-CXorf57 抗体

Anti-CXorf57 antibody

  • JP Deleterious:医薬用外劇物

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(2 Publications)

Rabbit Polyclonal CXorf57 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RADX.

別名を表示する

CXorf57, RADX, RPA-related protein RADX

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-CXorf57 antibody (AB228707)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CXorf57 antibody (AB228707)

SKNSH (Human neuroblastoma cell line) cells stained for CXorf57 protein (green) using ab228707 at 1/500 dilution in ICC/IF. Cells were fixed in 4% paraformaldehyde at RT for 15 minutes.

Nuclear counterstain : Hoechst 33342 (blue).

Western blot - Anti-CXorf57 antibody (AB228707)
  • WB

Supplier Data

Western blot - Anti-CXorf57 antibody (AB228707)

7.5% SDS-PAGE gel.

All lanes:

Western blot - Anti-CXorf57 antibody (ab228707) at 1/5000 dilution

Lane 1:

Non-transfected HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell extract at 30 µg

Lane 2:

CXorf57-transfected HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell extract at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG

Predicted band size: 98 kDa

true

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

ICC/IF, WB

applications

免疫原

Recombinant Fragment Protein within Human RADX. The exact immunogen used to generate this antibody is proprietary information.

Q6NSI4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CXorf57 also known as chromosome X open reading frame 57 is a protein encoded by the CXorf57 gene located on the X chromosome. The protein has a mass of approximately 26 kDa. It is expressed in various tissues with notable expression in the central nervous system including brain regions involved in cognitive functions. CXorf57 does not belong to any well-characterized family of proteins and remains an intriguing target for further functional elucidation.
Biological function summary

CXorf57 participates in cellular processes by acting as a regulatory protein. It does not form part of any known protein complexes but its role suggests involvement in transcriptional control. Researchers hypothesize that CXorf57 may have interactions with nuclear components due to its expression patterns and regulatory functions. Further functional studies are needed to detail the specific biological activities and interactions of CXorf57.

Pathways

CXorf57 intersects with signaling and developmental processes indicating a possible role in neural development pathways. Evidence suggests links to the PI3K-Akt pathway which involves proteins like Akt1 and is important for cell survival and growth. Such pathways are important for understanding how CXorf57 may influence cellular homeostasis and neuronal function.

CXorf57 has potential associations with neurological conditions such as intellectual disability and autism spectrum disorder. Alterations in CXorf57 expression or function could disrupt neuronal signaling contributing to these disorders. Interactions with proteins like MeCP2 have been noted which is relevant in the context of Rett syndrome and highlights the importance of understanding CXorf57 in neurodevelopmental disease contexts. Future research should aim to elucidate the precise mechanistic roles CXorf57 plays in these disease pathways.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed : 28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks (PubMed : 28735897).
See full target information RADX
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10:e2204961 PubMed36698265

2023

Reversing T Cell Dysfunction to Boost Glioblastoma Immunotherapy by Paroxetine-Mediated GRK2 Inhibition and Blockade of Multiple Checkpoints through Biomimetic Nanoparticles.

Applications

Unspecified application

Species

Unspecified reactive species

Tingting Wang,Hao Zhang,Yaobao Han,Qing Zheng,Hanghang Liu,Mengxiao Han,Zhen Li

Molecular cell 81:3128-3144.e7 PubMed34216544

2021

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency.

Applications

Unspecified application

Species

Unspecified reactive species

Ke Cong,Min Peng,Arne Nedergaard Kousholt,Wei Ting C Lee,Silviana Lee,Sumeet Nayak,John Krais,Pamela S VanderVere-Carozza,Katherine S Pawelczak,Jennifer Calvo,Nicholas J Panzarino,John J Turchi,Neil Johnson,Jos Jonkers,Eli Rothenberg,Sharon B Cantor
View all publications
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