Anti-CXCR2 (phospho S347) 抗体 (ab61100)
Key features and details
- Rabbit polyclonal to CXCR2 (phospho S347)
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-CXCR2 (phospho S347) antibody
CXCR2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to CXCR2 (phospho S347) -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Human CXCR2 aa 300-400 (phospho S347).
Database link: P25025 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol, 0.87% Sodium chloride -
Concentration information loading... -
精製度
Immunogen affinity purified -
特記事項（精製）
Purified from rabbit antiserum by affinity chromatography using epitope specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab61100の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P |
1/50 - 1/100.
|
| 特記事項 |
|---|
|
IHC-P
1/50 - 1/100. |
ターゲット情報
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機能
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. -
配列類似性
Belongs to the G-protein coupled receptor 1 family. -
翻訳後修飾
Phosphorylated upon ligand binding; which is required for desensitization. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 3579 Human
- Omim: 146928 Human
- SwissProt: P25025 Human
- Unigene: 846 Human
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別名
- C-X-C chemokine receptor type 2 antibody
- CD 182 antibody
- CD182 antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCR2 (phospho S347) antibody (ab61100)1/50-1/100 ab61100 staining phosphorilated CXCR2 on human breast carcinoma tissue, in the presence or absence of the immunizing phospopeptide.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab61100 は 3 報の論文で使用されています。
- Meng P et al. CXC Chemokine Receptor 2 Accelerates Tubular Cell Senescence and Renal Fibrosis via β-Catenin-Induced Mitochondrial Dysfunction. Front Cell Dev Biol 10:862675 (2022). PubMed: 35592244
- Cunha F et al. Electrical Stimulation Directs Migration, Enhances and Orients Cell Division and Upregulates the Chemokine Receptors CXCR4 and CXCR2 in Endothelial Cells. J Vasc Res 56:39-53 (2019). PubMed: 30995642
- Halpern JL et al. Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor. Cancer Lett 308:91-9 (2011). WB, ICC/IF ; Mouse . PubMed: 21601983