Anti-Cullin 7/CUL-7 抗体 (ab115304)
Key features and details
- Rabbit polyclonal to Cullin 7/CUL-7
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Cullin 7/CUL-7 antibody
Cullin 7/CUL-7 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Cullin 7/CUL-7 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Rat, Horse, Cow, Pig, Orangutan
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免疫原
Synthetic peptide corresponding to Human Cullin 7/CUL-7 aa 1650-1750 (C terminal) conjugated to keyhole limpet haemocyanin.
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ポジティブ･コントロール
- Human Brain, Cortex tissue
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
pH: 6
Preservative: 0.01% Sodium azide
Constituent: 99% Whole serum -
Concentration information loading... -
精製度
Whole antiserum -
特記事項（精製）
Delipidation and defibrination -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab115304の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P |
1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| 特記事項 |
|---|
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IHC-P
1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ターゲット情報
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機能
Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation (By similarity). Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity. -
組織特異性
Highly expressed in fetal kidney and adult skeletal muscle. Also abundant in fetal brain, as well as in adult pancreas, kidney, placenta and heart. Detected in trophoblasts, lymphoblasts, osteoblasts, chondrocytes and skin fibroblasts. -
パスウェイ
Protein modification; protein ubiquitination. -
関連疾患
Defects in CUL7 are the cause of 3M syndrome type 1 (3M1) [MIM:273750]. An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies. -
配列類似性
Belongs to the cullin family.
Contains 1 DOC domain. -
細胞内局在
Cytoplasm. - Information by UniProt
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参照データベース
- Entrez Gene: 504558 Cow
- Entrez Gene: 100067262 Horse
- Entrez Gene: 9820 Human
- Entrez Gene: 100172168 Orangutan
- Entrez Gene: 363191 Rat
- Omim: 609577 Human
- SwissProt: Q14999 Human
- SwissProt: Q5RCJ3 Orangutan
see all -
別名
- CUL-7 antibody
- CUL7 antibody
- CUL7_HUMAN antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cullin 7/CUL-7 antibody (ab115304)
ab115304, at 1/500 dilution, staining Cullin 7/CUL-7 in formalin-fixed, paraffin-embedded Human Brain, Cortex tissue by Immunohistochemistry, using a biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab115304 は論文での使用が確認できていません。