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AB136038

Anti-CTDSP1 抗体

Anti-CTDSP1 antibody

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(1 Publication)

Rabbit Polyclonal CTDSP1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CTDSP1.

別名を表示する

NIF3, NLIIF, SCP1, CTDSP1, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, Nuclear LIM interactor-interacting factor 3, Small C-terminal domain phosphatase 1, NLI-IF, NLI-interacting factor 3, Small CTD phosphatase 1

1 Images
Western blot - Anti-CTDSP1 antibody (AB136038)
  • WB

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Western blot - Anti-CTDSP1 antibody (AB136038)

All lanes:

Western blot - Anti-CTDSP1 antibody (ab136038) at 1/500 dilution

All lanes:

HepG2 cell lysate at 30 µg

Predicted band size: 29 kDa,35 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Synthetic Peptide within Human CTDSP1. The exact immunogen used to generate this antibody is proprietary information.

Q9GZU7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CTDSP1 also known as CTD small phosphatase 1 functions as an enzyme that dephosphorylates the C-terminal domain (CTD) of RNA polymerase II. This process regulates transcription elongation and termination. CTDSP1 has a molecular mass of approximately 30 kDa. The protein expresses widely with high levels found in the brain and ovary. It primarily operates within the nucleus reflecting its role in transcription regulation.
Biological function summary

CTDSP1 is involved in gene expression regulation by influencing RNA polymerase II activity. It belongs to a phosphatase family with related proteins like CTDSP2 and CTDSPL sharing overlapping functions. As a part of the CTD phosphatase complex CTDSP1 coordinates with other molecular players to manage gene expression outputs. This regulatory mechanism helps modulate responses to external and internal cellular signals.

Pathways

CTDSP1 takes part in the larger RNA transcription and processing pathways particularly the regulation of RNA polymerase II transcription. CTDSP1 interacts with factors like pre-mRNA splicing components affecting gene expression outcomes. It is associated with pathways that involve Cyclin-dependent kinase 9 (CDK9) which also influences RNA polymerase II activity through phosphorylation events demonstrating its key physiological interactions.

CTDSP1 has associations with neurological conditions and cancer. Its involvement in modulating gene expression links it to neurodegenerative disorders like Alzheimer's disease where transcription regulation plays a significant role in disease progression. Additionally changes in CTDSP1 activity relate to tumorigenesis with alterations in CTDSP1 or interacting proteins like CTDSP2 observed in various cancers. This makes CTDSP1 an interesting target for further research into diagnostic and therapeutic applications.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
See full target information CTDSP1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

BMC biology 22:83 PubMed38609948

2024

Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Svetlana B Panina,Joshua V Schweer,Qian Zhang,Gaurav Raina,Haley A Hardtke,Seungjin Kim,Wanjie Yang,Dionicio Siegel,Y Jessie Zhang
View all publications
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