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AB140773

Anti-CRLR 抗体 - N-terminal

Anti-CRLR antibody - N-terminal

4

(1 Review)

|

(1 Publication)

Rabbit Polyclonal CRLR antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CALCRL.

別名を表示する

CGRPR, CALCRL, Calcitonin gene-related peptide type 1 receptor, CGRP type 1 receptor, Calcitonin receptor-like receptor, CRLR

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRLR antibody - N-terminal (AB140773)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRLR antibody - N-terminal (AB140773)

Immunohistochemical analysis of formalin-fixed, paraffin embedded Human colon tissue (submucosal vessels) labelling CRLR with ab140773 at 16 µg/ml.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P

applications

免疫原

Synthetic Peptide within Human CALCRL. The exact immunogen used to generate this antibody is proprietary information.

Q16602

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代替製品

Primary Antibodies

AB140761

Anti-CRLR antibody - Cytoplasmic domain

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRLR antibody - Cytoplasmic domain (AB140761)

  • 2
  • 3

組合せ製品

Primary Antibodies

AB156575

Anti-RAMP1 antibody [EPR10867]

RabMAb|Recombinant

Western blot - Anti-RAMP1 antibody [EPR10867] (AB156575)

  • 4
  • 3
Primary Antibodies

AB81887

Anti-CGRP antibody [4901]

Immunocytochemistry/ Immunofluorescence - Anti-CGRP antibody [4901] (AB81887)

  • 5
  • 9
Primary Antibodies

AB230500

Anti-Calcitonin receptor/CT-R antibody

Immunocytochemistry/ Immunofluorescence - Anti-Calcitonin receptor/CT-R antibody (AB230500)

  • 0
  • 0
Primary Antibodies

AB200315

Alexa Fluor® 488 Anti-CD45 antibody [EP322Y]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Alexa Fluor® 488 Anti-CD45 antibody [EP322Y] (AB200315)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "16 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Calcitonin Receptor-Like Receptor (CRLR) also known as the calcitonin receptor-like receptor functions as a G-protein-coupled receptor involved in the regulation of various physiological processes. CRLR has a molecular mass of approximately 55 kDa. This receptor is broadly expressed in numerous tissues including the cardiovascular system the central nervous system and peripheral tissues. As a receptor CRLR plays a central role in signal transduction by binding to specific peptide ligands mainly through interaction with receptor activity-modifying proteins (RAMPs) which are essential for its functional specificity.
Biological function summary

CRLR operates as part of a receptor complex with RAMPs that determines its ligand specificity; this complex enables it to bind peptides such as adrenomedullin and calcitonin gene-related peptide (CGRP). When combined with different RAMPs CRLR can switch its ligand affinity and function as adrenomedullin or CGRP receptors therefore influencing vascular tone pain transmission and metabolic regulation. Research demonstrates that CRLR and its associated complexes contribute to processes like vasodilation angiogenesis and neurogenic inflammation emphasizing its role in maintaining homeostasis.

Pathways

CRLR actively participates in critical biological pathways particularly the signaling pathways of CGRP and adrenomedullin which are significant in cardiovascular and nervous system functions. Within these pathways CRLR modulates the activity of secondary messengers such as cyclic AMP (cAMP) upon ligand binding therefore initiating further downstream effects in target cells. Related proteins including RAMPs and components of cAMP signaling work in conjunction with CRLR to ensure precise cellular responses to ligand stimulation linking it to broader physiological processes like stress response and blood pressure regulation.

CRLR stands associated with conditions such as migraines and heart failure. The ability of CRLR to bind CGRP makes it a target for migraine therapies as CGRP plays a pivotal role in migraine pathophysiology. Additionally CRLR through its regulation of adrenomedullin becomes linked to heart failure given adrenomedullin's effects on vasodilation and cardiac function. In these pathological conditions CRLR often interacts with RAMPs influencing the severity and progression of the disease capturing interest for therapeutic interventions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs) (PubMed : 32296767, PubMed : 33602864, PubMed : 8626685). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2 (PubMed : 33602864). Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2) (PubMed : 32296767, PubMed : 9620797). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed : 32296767, PubMed : 8626685).
See full target information CALCRL
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Science immunology 6: PubMed33622974

2021

Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Zhao,Christoph Kilian,Jan-Eric Turner,Lidia Bosurgi,Kevin Roedl,Patricia Bartsch,Ann-Christin Gnirck,Filippo Cortesi,Christoph Schultheiß,Malte Hellmig,Leon U B Enk,Fabian Hausmann,Alina Borchers,Milagros N Wong,Hans-Joachim Paust,Francesco Siracusa,Nicola Scheibel,Marissa Herrmann,Elisa Rosati,Petra Bacher,Dominik Kylies,Dominik Jarczak,Marc Lütgehetmann,Susanne Pfefferle,Stefan Steurer,Julian Schulze Zur-Wiesch,Victor G Puelles,Jan-Peter Sperhake,Marylyn M Addo,Ansgar W Lohse,Mascha Binder,Samuel Huber,Tobias B Huber,Stefan Kluge,Stefan Bonn,Ulf Panzer,Nicola Gagliani,Christian F Krebs
View all publications
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