AB6588

Anti-Collagen VI 抗体

Name: Anti-Collagen VI 抗体 (ab6588) | Abcam
Brand: Abcam Limited
SKU: AB6588
Price: 72000 JPY
Availability: InStock
Rating: 5 (21 reviews)

Anti-Collagen VI antibody

(21 Reviews)

(183 Publications)

Anti-Collagen VI antibody (ab6588) is a rabbit polyclonal antibody detecting Collagen VI in Western Blot. Suitable for Human.

- Over 150 publications
- Trusted since 2002

別名を表示する

Collagen alpha-1(VI) chain, COL6A1

1 Images

Unknown

Western blot - Anti-Collagen VI antibody (AB6588)

All lanes:

Western blot - Anti-Collagen VI antibody (ab6588) at 1/5000 dilution

All lanes:

HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate at 10 µg

Secondary

All lanes:

Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Predicted band size: 109 kDa

Observed band size: 100 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

applications

免疫原

Native Full Length Protein corresponding to Human COL6A1.

P12109

特異性

Some class-specific anti-collagens may be specific for three-dimensional epitopes which may result in diminished reactivity with denatured collagen or formalin-fixed, paraffin embedded tissues. This antibody reacts with most mammalian Type VI collagens and has negligible cross-reactivity with Type I, II, III, IV or V collagens. Non-specific cross-reaction of anti-collagen antibodies with other human serum proteins or non-collagen extracellular matrix proteins is negligible.

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Reactivity data

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製品の詳細

What is this antibody validated in?
Anti-Collagen VI antibody (ab6588) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB) in Human samples.

What is the molecular weight of Collagen VI?
Anti-Collagen VI (ab6588) specifically detects a band for Collagen VI (UniProt: P12109) at a molecular weight of 108kDa.

Trusted by the scientific community
Anti-Collagen VI (ab6588) was first used in a scientific publication in 2002 and has been cited over 150 times in peer-reviewed journals.

Reviewed by scientists
Anti-Collagen VI (ab6588) has over 20 independent reviews from customers.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

精製に関する特記事項

Anti-Collagen Type VI has been prepared by immunoaffinity chromatography using immobilized antigens followed by extensive cross-adsorption against other collagens, human serum proteins and non-collagen extracellular matrix proteins to remove any unwanted specificities.

バッファー組成

pH: 7.2 Preservative: 0.01% Sodium azide Constituents: 0.88% Sodium chloride, 0.424% Potassium phosphate solution

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Collagen VI also known as Collagen 6 is a type of collagen that plays an important role in the extracellular matrix. It consists of three different chains: α1(VI) α2(VI) and α3(VI) with a combined mass of approximately 140 kDa. This collagen type strongly associates with several tissues notably in skeletal muscle skin and the walls of blood vessels. Scientists often study collagen VI with specific collagen antibodies to understand its unique structural properties and its end which binds to other matrix components.

Biological function summary

Collagen VI contributes to structural integrity and cellular scaffolding within tissues. This protein is integral to the formation of microfibrillar networks part of a larger complex that connects the extracellular matrix to cells and other matrix components. Its protective role helps cells resist mechanical stress and the network provided by collagen VI powder stabilizes the tissue architecture. Additionally low endotoxin collagen is often preferable in research to minimize inflammatory responses during experimentation providing more accurate results.

Pathways

Collagen VI participates in extracellular matrix organization and mechanotransduction pathways. It functions alongside other proteins like collagen I and IV. In particular collagen VI interacts with cell surface receptors which influences cellular communication and signaling pathways. This interaction plays a role in transmitting mechanical signals that affect cellular behavior and function proving important for tissue maintenance and repair processes.

Mutations or malfunctions involving collagen VI can lead to significant clinical outcomes. It is prominently linked with disorders such as Ullrich congenital muscular dystrophy and Bethlem myopathy both affecting muscle and connective tissue. These conditions often involve disruptions in the assembly or function of the collagen VI network. Additionally related proteins like collagen I and integrin proteins can influence the progression and severity of these disorders illustrating the interconnected nature of these extracellular elements.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Collagen VI acts as a cell-binding protein.

See full target information COL6A1

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文献 (183)

Recent publications for all applications. Explore the full list and refine your search

Life science alliance 8: PubMed41034152

2025

Combined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and skin phenotypes.

Applications

Unspecified application

Species

Unspecified reactive species

Nandaraj Taye,Stylianos Z Karoulias,Zerina Balic,Lauren W Wang,Belinda B Willard,Daniel Martin,Daniel Richard,Alexander S Okamoto,Terence D Capellini,Suneel S Apte,Dirk Hubmacher

eLife 12: PubMed41025959

2025

Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI.

Applications

Unspecified application

Species

Unspecified reactive species

Alexander N Kapustin,Sofia Serena Tsakali,Meredith Whitehead,George Chennell,Meng-Ying Wu,Chris Molenaar,Anton Kutikhin,Yimeng Chen,Sadia Ahmad,Leo Bogdanov,Maxim Sinitsky,Kseniya Rubina,Aled Clayton,Frederik J Verweij,Dirk Michiel Pegtel,Simona Zingaro,Arseniy Lobov,Bozhana Zainullina,Dylan Owen,Maddy Parsons,Richard E Cheney,Derek T Warren,Martin James Humphries,Thomas Iskratsch,Mark Holt,Catherine M Shanahan

Nature 646:934-944 PubMed40903576

2025

Dynamic fibroblast-immune interactions shape recovery after brain injury.

Applications

Unspecified application

Species

Unspecified reactive species

Nathan A Ewing-Crystal,Nicholas M Mroz,Amara Larpthaveesarp,Carlos O Lizama,Remy Pennington,Pailin Chiaranunt,Jason I Dennis,Anthony A Chang,Eric Dean Merrill,Sofia E Caryotakis,Nikhita Kirthivasan,Leon Teo,Tatsuya Tsukui,Aditya Katewa,Gabriel L McKinsey,Sophia C K Nelson,Agnieszka Ciesielska,Nicole C Lummis,Lucija Pintarić,Madelene W Dahlgren,Amha Atakilit,Helena Paidassi,Saket Jain,Xiaodan Liu,Duan Xu,Manish K Aghi,James A Bourne,Jeanne T Paz,Richard Daneman,Fernando F Gonzalez,Dean Sheppard,Anna V Molofsky,Thomas D Arnold,Ari B Molofsky

PLoS genetics 21:e1011806 PubMed40825068

2025

The glycosyltransferase POGLUT1 regulates muscle stem cell development and maintenance in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Soomin Cho,Emilia Servián-Morilla,Victoria Navarro,Beatriz Rodriguez-Gonzalez,Youxi Yuan,Raquel Cano,Arjun A Rambhiya,Radbod Darabi,Robert S Haltiwanger,Carmen Paradas,Hamed Jafar-Nejad

International journal of molecular sciences 26: PubMed40649868

2025

Furosemide Promotes Inflammatory Activation and Myocardial Fibrosis in Swine with Tachycardia-Induced Heart Failure.

Applications

Unspecified application

Species

Unspecified reactive species

Nisha Plavelil,Robert Goldstein,Michael G Klein,Luke Michaelson,Mark C Haigney,Maureen N Hood

Neuropathology and applied neurobiology 51:e70020 PubMed40400418

2025

Collablots: Quantification of Collagen VI Levels and Its Structural Disorganisation in Cell Cultures From Patients With Collagen VI-Related Dystrophies.

Applications

Unspecified application

Species

Unspecified reactive species

Nadia Osegui-Barcenilla,Maria Sendino,Sergio Martín-González,Itziar González-Moro,Ainhoa Benito-Agustino,Noemi Torres-Conde,Andrea López-Martínez,Cecilia Jiménez-Mallebrera,Arístides López-Márquez,Virginia Arechavala-Gomeza

The Journal of clinical investigation 135: PubMed40309777

2025

Collagen type VI regulates TGF-β bioavailability in skeletal muscle in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Payam Mohassel,Hailey Hearn,Jachinta Rooney,Yaqun Zou,Kory Johnson,Gina Norato,Matthew A Nalls,Pomi Yun,Tracy Ogata,Sarah Silverstein,David A Sleboda,Thomas J Roberts,Daniel B Rifkin,Carsten G Bönnemann

Neuropathology and applied neurobiology 51:e70014 PubMed40164574

2025

Computational Analysis of SOD1-G93A Mouse Muscle Biomarkers for Comprehensive Assessment of ALS Progression.

Applications

Unspecified application

Species

Unspecified reactive species

Pedro Gómez-Gálvez,Victoria Navarro,Ana M Castro,Carmen Paradas,Luis M Escudero

Cartilage :19476035241313179 PubMed39925233

2025

Cartilage Organoids from Articular Chondroprogenitor Cells and Their Potential to Produce Neo-Hyaline Cartilage.

Applications

Unspecified application

Species

Unspecified reactive species

Daphne M A Menssen,Jeske C A Feenstra,Rob P A Janssen,Florencia Abinzano,Keita Ito

Frontiers in cardiovascular medicine 11:1430772 PubMed39691494

2024

Protective effect of UDCA against IL-11- induced cardiac fibrosis is mediated by TGR5 signalling.

Applications

Unspecified application

Species

Unspecified reactive species

B Reilly-O'Donnell,E Ferraro,R Tikhomirov,R Nunez-Toldra,A Shchendrygina,L Patel,Y Wu,A L Mitchell,A Endo,L Adorini,R A Chowdhury,P K Srivastava,F S Ng,C Terracciano,C Williamson,J Gorelik

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Collagen VI 抗体

Anti-Collagen VI antibody

Western blot - Anti-Collagen VI antibody (AB6588)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

特異性

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (183)

代替製品

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Primary Antibodies

Primary Antibodies

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Primary Antibodies

組合せ製品

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Secondary Antibodies

Abcam product promise