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AB20447

Anti-Clostridium 抗体

Anti-Clostridium antibody

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(1 Publication)

Rabbit Polyclonal Clostridium antibody. Suitable for ICC/IF and reacts with Clostridium samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing Clostridium protein.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Clostridium

アプリケーション

ICC/IF

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特異性

Reactive with proteins from common Clostridia species. Antiserum is not absorbed and may react with related microorganisms. Reactive (IFA) with Cl. perfingens, Cl. sordellii, Cl. novyi, Cl. septicum, Cl. chauvoei.

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Clostridium": { "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p>This antibody may be used in place of neat antiserum in almost any appropriate antibody-based technique and is also suitable for conjugation purposes.</p>" } } }

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
Preservative: 0.1% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Clostridium a genus of gram-positive bacteria includes species known for producing toxins and spores. These bacteria have a variable mass since the genus comprises various species. Clostridium is commonly found in anaerobic environments like soil water and decomposing plant material. Some species are part of the normal gut microbiota in humans and animals. The genera's toxins such as botulinum and tetanus are significant in both clinical and research settings due to their potent biological effects.
Biological function summary

Clostridium species impact human health through toxin production affecting neurological and muscular systems. Some species like Clostridium botulinum and Clostridium tetani produce neurotoxins that interfere with synaptic transmissions. These bacteria are part of complex inter-organismal networks within the microbiome influencing other microbial community members through competitive or symbiotic interactions. The toxins produced by clostridial species target specific cells binding to receptors and disrupting normal cellular function.

Pathways

Clostridium species influence key biological processes notably the neuromuscular junction and gastrointestinal pathways. Clostridial toxins such as botulinum toxin block acetylcholine release which inhibits muscle contractions and affects communication between nerves and muscles. This interaction links Clostridium to proteins involved in synaptic vesicle docking and release. These species also interact with intestinal microbial pathways impacting nutrient absorption and gut health.

Clostridium species cause conditions like botulism and tetanus. Botulism results from botulinum toxin interfering with motor neurons leading to paralysis. In tetanus tetanospasmin disrupts inhibitory neurons causing muscle rigidity and spasms. Clostridial toxins like botulinum and tetanus target critical proteins such as SNARE proteins involved in neurotransmitter release leading to these disorders' characteristic symptoms. Understanding these interactions is essential for developing treatments against clostridial diseases.

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

ターゲットの情報

See full target information Clostridium

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Molecules (Basel, Switzerland) 26: PubMed34641603

2021

Anti-Herpes Simplex 1 Activity of (Jojoba) Wax.

Applications

Unspecified application

Species

Unspecified reactive species

Zipora Tietel,Sarit Melamed,Noy Eretz-Kdosha,Ami Guetta,Raanan Gvirtz,Navit Ogen-Shtern,Arnon Dag,Guy Cohen
View all publications

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