Anti-Claudin 1 抗体 [SP128] (ab115783)
![Flow Cytometry - Anti-Claudin 1 antibody [SP128] (ab115783)](https://www.abcam.co.jp/ps/products/115/ab115783/Images/ab115783-215428-anti-claudin-1-antibody-sp128-flow-cytometry.jpg "Flow Cytometry - Anti-Claudin 1 antibody [SP128] (ab115783)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [SP128] to Claudin 1
- Suitable for: WB, IHC-P, Flow Cyt
- Reacts with: Human
Related conjugates and formulations
製品の概要
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製品名
Anti-Claudin 1 antibody [SP128]
Claudin 1 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [SP128] to Claudin 1 -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-P, Flow Cytmore details -
種交差性
交差種: Human
交差が予測される動物種: Cow, Pig
非交差種:
Mouse, Rat -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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ポジティブ･コントロール
- Human liver carcinoma tissue
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特記事項
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading... -
精製度
Protein A/G purified -
特記事項（精製）
Purified from TCS by protein A/G. -
ポリ/モノ
モノクローナル -
クローン名
SP128 -
アイソタイプ
IgG -
研究分野
関連製品
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Alternative Versions
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab115783の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/1000. Predicted molecular weight: 22 kDa.
|
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| IHC-P |
1/200. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
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|
| Flow Cyt |
1/100.
ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody. |
| 特記事項 |
|---|
|
WB
1/1000. Predicted molecular weight: 22 kDa. |
|
IHC-P
1/200. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. |
|
Flow Cyt
1/100. ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody. |
ターゲット情報
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機能
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391).
(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes (PubMed:17325668). Acts as a receptor for dengue virus (PubMed:24074594). -
組織特異性
Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. -
関連疾患
Ichthyosis-sclerosing cholangitis neonatal syndrome -
配列類似性
Belongs to the claudin family. -
細胞内局在
Cell junction, tight junction. Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 414922 Cow
- Entrez Gene: 9076 Human
- Omim: 603718 Human
- SwissProt: Q6L708 Cow
- SwissProt: O95832 Human
- Unigene: 439060 Human
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別名
- Claudin-1 antibody
- Claudin1 antibody
- CLD 1 antibody
see all
画像
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Flow Cytometry - Anti-Claudin 1 antibody [SP128] (ab115783)
Flow cytometric analysis of rabbit anti-Claudin 1 (SP128) antibody ab115783 (1/100) in HepG2 cells(green) compared to negative control of rabbit IgG (blue).
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 1 antibody [SP128] (ab115783)](https://www.abcam.co.jp/ps/products/115/ab115783/Images/ab115783-127922-anti-claudin-1-antibody-sp128-immunohistochemistry.jpg)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 1 antibody [SP128] (ab115783)Staining of Human Claudin 1 in a Formalin/PFA-fixed paraffin-embedded section of Human Liver Carcinoma using ab115783 at a dilution of 1/200. -
![Anti-Claudin 1 antibody [SP128] (ab115783)](https://www.abcam.co.jp/ps/products/115/ab115783/Images/ab115783-3-benefits-of-recombinant-antibodies.png)
Anti-Claudin 1 antibody [SP128] (ab115783)
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab115783 は論文での使用が確認できていません。