Anti-CIT 抗体 (ab110897)
Key features and details
- Rabbit polyclonal to CIT
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-CIT antibody
CIT 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to CIT -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse
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免疫原
Synthetic peptide corresponding to Human CIT aa 1000-1100 (internal sequence).
Database link: O14578 -
ポジティブ･コントロール
- Human brain tissue
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.88% Sodium chloride, 50% Glycerol (glycerin, glycerine)
PBS (without Mg2+ and Ca2+) -
Concentration information loading... -
精製度
Immunogen affinity purified -
特記事項（精製）
ab110897 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab110897の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P |
1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| 特記事項 |
|---|
|
IHC-P
1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ターゲット情報
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機能
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. -
配列類似性
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 CNH domain.
Contains 1 PH domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 protein kinase domain. -
細胞内局在
Cytoplasm. - Information by UniProt
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参照データベース
- Entrez Gene: 11113 Human
- Entrez Gene: 12704 Mouse
- Omim: 605629 Human
- SwissProt: O14578 Human
- SwissProt: P49025 Mouse
- Unigene: 119594 Human
- Unigene: 426282 Mouse
- Unigene: 8321 Mouse
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別名
- CIT antibody
- Citron (rho interacting serine/threonine kinase 21) antibody
- Citron antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CIT antibody (ab110897)ab110897, at a 1/50 dilution, staining CIT in paraffin-embedded Human brain tissue by Immunohistochemistry. The image on the right is treated with the synthesized peptide.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab110897 は 3 報の論文で使用されています。
- Liu Z et al. Novel circRNA_0071196/miRNA-19b-3p/CIT axis is associated with proliferation and migration of bladder cancer. Int J Oncol 57:767-779 (2020). PubMed: 32705161
- Zhang HQ et al. Low expression of citron kinase is associated with poor patient outcomes in hepatocellular carcinoma. Transl Cancer Res 9:2416-2423 (2020). PubMed: 35117601
- Wu Z et al. Up-regulation of CIT promotes the growth of colon cancer cells. Oncotarget 8:71954-71964 (2017). PubMed: 29069760