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AB167377

Anti-CHD2 抗体

Anti-CHD2 antibody

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(1 Publication)

Mouse Polyclonal CHD2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CHD2.

別名を表示する

Chromodomain-helicase-DNA-binding protein 2, CHD-2, ATP-dependent helicase CHD2, CHD2

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-CHD2 antibody (AB167377)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CHD2 antibody (AB167377)

Immunofluorescence analysis of HeLa cells labeling CHD2 with ab167377 at 10 ug/ml

Western blot - Anti-CHD2 antibody (AB167377)
  • WB

Unknown

Western blot - Anti-CHD2 antibody (AB167377)

All lanes:

Western blot - Anti-CHD2 antibody (ab167377) at 1 µg/mL

Lane 1:

CHD2 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Predicted band size: 55.11 kDa

true

Key facts

宿主種

Mouse

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

ICC/IF, WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human CHD2.

O14647

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The CHD2 protein also known as Chromodomain-Helicase-DNA-binding protein 2 acts as an ATP-dependent chromatin remodeler. This protein has a mass of approximately 210 kDa. CHD2 is expressed in various tissues with higher expression levels noted in the brain and skeletal muscle. As a part of the chromatin remodeling family CHD2 plays a role in modifying the structure of chromatin to affect gene expression.
Biological function summary

CHD2 contributes to DNA repair and transcription regulation by modifying chromatin structure. It is a part of the CHD family of chromatin remodelers which influences nucleosome positioning and accessibility. By facilitating transcription CHD2 impacts gene expression necessary for neural development and other processes. CHD2 functions as a monomer and does not form larger protein complexes.

Pathways

CHD2 influences gene expression regulation and neural development. It plays a role in the transcriptional regulation pathway by interacting with chromatin to control the accessibility of transcription factors. The protein links with others like CHD3 and CHD4 within this pathway to coordinate chromatin conformation changes necessary for proper transcription processes.

The CHD2 protein relates to epileptic encephalopathy and neurodevelopmental disorders. Mutations in the CHD2 gene associate with these conditions affecting neurological function and development. CHD2 mutations often coexist with other genetic factors involving proteins like SCN1A contributing to the complex nature of these disorders.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1 : binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity).
See full target information CHD2
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Phytotherapy research : PTR 38:5441-5457 PubMed39289784

2024

Geniposidic Acid Attenuates Chronic Tubulointerstitial Nephropathy Through Regulation of the NF-ƙB/Nrf2 Pathway Via Aryl Hydrocarbon Receptor Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yan-Ni Wang,Xiao-Jun Li,Wen-Feng Wang,Liang Zou,Hua Miao,Ying-Yong Zhao
View all publications
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Abcam product promise

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