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AB121196

Anti-CHCHD10 抗体

Anti-CHCHD10 antibody

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(6 Publications)

Rabbit Polyclonal CHCHD10 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CHCHD10 aa 1 to C-terminus.

別名を表示する

C22orf16, CHCHD10, Protein N27C7-4

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHCHD10 antibody (AB121196)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHCHD10 antibody (AB121196)

Immunohistochemical analysis of human liver tissue sections labeling CHCHD10 with ab121196 at 1/200.

Immunocytochemistry/ Immunofluorescence - Anti-CHCHD10 antibody (AB121196)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CHCHD10 antibody (AB121196)

Immunofluorescent staining of Human cell line A-431 shows positivity in mitochondria. Recommended concentration of ab121196 1-4 μg/ml. Cells treated with PFA/Triton X-100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHCHD10 antibody (AB121196)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHCHD10 antibody (AB121196)

Immunohistochemical analysis of human skeletal muscle tissue sections labeling CHCHD10 with ab121196 at 1/200.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHCHD10 antibody (AB121196)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHCHD10 antibody (AB121196)

Immunohistochemical analysis of human skin tissue sections labeling CHCHD10 with ab121196 at 1/200.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHCHD10 antibody (AB121196)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHCHD10 antibody (AB121196)

Immunohistochemical analysis of human colon tissue sections labeling CHCHD10 with ab121196 at 1/200.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

ICC/IF, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human CHCHD10 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8WYQ3

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組合せ製品

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Western blot - Total OXPHOS Rodent WB Antibody Cocktail (AB110413)

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Primary Antibodies

AB110329

Anti-Mitofilin antibody [2E4AD5] - Mitochondrial Marker

Lab Essentials

Western blot - Anti-Mitofilin antibody [2E4AD5] - Mitochondrial Marker (AB110329)

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  • 3
Primary Antibodies

AB52623

Anti-beta III Tubulin antibody [EP1569Y] - Neuronal Marker

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Immunocytochemistry/ Immunofluorescence - Anti-beta III Tubulin antibody [EP1569Y] - Neuronal Marker (AB52623)

  • 5
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Reagents, Controls & Accessories

AB119211

InstantBlue® Coomassie Protein Stain (ISB1L)

Western blot - InstantBlue® Coomassie Protein Stain (ISB1L) (AB119211)

  • 5
  • 5
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The CHCHD10 protein also known as coiled-coil-helix-coiled-coil-helix domain containing 10 is a mitochondrial protein with a molecular weight of approximately 14 kDa. It is specifically localized within the intermembrane space of mitochondria and is expressed in various tissues with high levels in the brain heart and skeletal muscles. CHCHD10 plays a role in maintaining mitochondrial structure and function contributing to the stability and regulation of mitochondrial cristae.
Biological function summary

The CHCHD10 protein participates in mitochondrial processes that regulate cellular energy production and apoptosis. It is part of a complex network within mitochondria interacting with other proteins to support mitochondrial DNA maintenance and oxidative phosphorylation. Its presence helps maintain cellular homeostasis by preventing mitochondrial dysfunction which can otherwise trigger oxidative stress and cellular damage.

Pathways

CHCHD10 is integral in the maintenance of mitochondrial quality control and respiratory pathways. It is involved in the mitochondrial inner membrane organizing system (MINOS) complex that is important for organizing and stabilizing mitochondrial membrane structure. CHCHD10 also interacts with proteins like OPA1 and CHCHD2 which are important for mitochondrial dynamics and energy regulation demonstrating its key role in these pathways.

CHCHD10 mutations are linked to conditions like amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The interaction between CHCHD10 and other mitochondria-related proteins like SOD1 and TDP-43 highlights its role in the pathogenesis of these neurodegenerative diseases. These mutations lead to mitochondrial dysfunction which contributes to the degeneration of motor neurons in ALS and the degeneration of frontal and temporal lobes in FTD.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure.
See full target information CHCHD10
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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:7121 PubMed40753073

2025

Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Guohua Lv,Nicole M Sayles,Yun Huang,Chiara Mancinelli,Kevin McAvoy,Neil A Shneider,Giovanni Manfredi,Hibiki Kawamata,David Eliezer

Cells 12: PubMed38132101

2023

Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion.

Applications

Unspecified application

Species

Unspecified reactive species

Tian Liu,Liam Wetzel,Zexi Zhu,Pavan Kumaraguru,Viraj Gorthi,Yan Yan,Mohammed Zaheen Bukhari,Aizara Ermekbaeva,Hanna Jeon,Teresa R Kee,Jung-A Alexa Woo,David E Kang

Human molecular genetics 31:3987-4005 PubMed35786718

2022

Pathological characterization of a novel mouse model expressing the PD-linked CHCHD2-T61I mutation.

Applications

Unspecified application

Species

Unspecified reactive species

Teresa R Kee,Jessica L Wehinger,Pamela Espinoza Gonzalez,Eric Nguyen,Kyle C McGill Percy,Sophia A Khan,Dale Chaput,Xinming Wang,Tian Liu,David E Kang,Jung-A A Woo

Acta neuropathologica communications 10:95 PubMed35787294

2022

Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10.

Applications

Unspecified application

Species

Unspecified reactive species

Tian Liu,Jung-A A Woo,Mohammed Zaheen Bukhari,Xinming Wang,Yan Yan,Sara Cazzaro Buosi,Aizara Ermekbaeva,Apoorva Sista,Peter Kotsiviras,Patrick LePochat,Ann Chacko,Xingyu Zhao,David E Kang

FASEB journal : official publication of the Federa 34:8493-8509 PubMed32369233

2020

CHCHD10-regulated OPA1-mitofilin complex mediates TDP-43-induced mitochondrial phenotypes associated with frontotemporal dementia.

Applications

Unspecified application

Species

Unspecified reactive species

Tian Liu,Jung-A A Woo,Mohammed Zaheen Bukhari,Patrick LePochat,Ann Chacko,Maj-Linda B Selenica,Yan Yan,Peter Kotsiviras,Sara Cazzaro Buosi,Xingyu Zhao,David E Kang

EMBO molecular medicine 10: PubMed29789341

2018

A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS.

Applications

ICC/IF, WB

Species

Unspecified reactive species, Unspecified reactive species

Carina Lehmer,Martin H Schludi,Linnea Ransom,Johanna Greiling,Michaela Junghänel,Nicole Exner,Henrick Riemenschneider,Julie van der Zee,Christine Van Broeckhoven,Patrick Weydt,Michael T Heneka,Dieter Edbauer
View all publications
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