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AB135271

Anti-CGRP 抗体

Anti-CGRP antibody

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(5 Publications)

Rabbit Polyclonal CGRP-I antibody. Suitable for IHC-P and reacts with Human samples. Cited in 5 publications.

別名を表示する

CALC1, CALCA, Calcitonin gene-related peptide 1, CGRP1, Alpha-type CGRP, Calcitonin gene-related peptide I, CGRP-I

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CGRP antibody (AB135271)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CGRP antibody (AB135271)

Immunohistochemical analysis of paraffin-embedded Human prostate carcinoma tissue labelling CGRP with ab135271 at 1/50 dilution.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
精製に関する特記事項
ab135271 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CGRP or Calcitonin Gene-Related Peptide is a 37-amino acid neuropeptide with a molecular mass of approximately 3.8 kDa. This peptide exists mainly in two forms alpha-CGRP and beta-CGRP differing slightly in amino acid sequence. CGRP expresses in peripheral and central nervous systems with high levels in the dorsal root ganglia and thyroid gland. It also has a significant presence in the enteric nervous system and some segments of the cardiovascular system. Scientists note that CGRP acts as a potent vasodilator and plays a significant role in transducing pain signals.
Biological function summary

CGRP contributes to numerous physiological processes including blood flow regulation body temperature control pain transmission and neurogenic inflammation. It acts independently and does not substantially form part of larger protein complexes in its primary activities. Through binding to the CGRP receptor a complex made up of the calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) CGRP initiates downstream signaling that results in its various biological effects.

Pathways

Studies place CGRP within the neuropeptide signaling pathway and the vasodilation pathway. It significantly influences the cyclic AMP (cAMP) signaling pathway where it works collaboratively with other neuropeptides like substance P. The interaction with CLR and RAMP1 triggers the production of cAMP which enhances vasodilation and pain transmission processes in the body.

CGRP holds a notable connection to migraines and cardiovascular diseases. Elevated CGRP levels are observed in migraine sufferers and targeted treatments utilizing anti-CGRP antibodies have demonstrated efficacy in reducing migraine frequency. Additionally research links CGRP to blood pressure regulation abnormalities implicating its involvement in hypertension. Both conditions involve complex interactions with other proteins such as substance P and endothelial nitric oxide synthase (eNOS) which modulate vascular tone and inflammation.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex (PubMed : 1318039, PubMed : 33602864, PubMed : 9620797). Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role (PubMed : 3492492). It also elevates platelet cAMP (PubMed : 1318039). CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex (PubMed : 38603770).
See full target information CALCA
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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Nature protocols : PubMed40707741

2025

Printed photonic crystal biochips for rapid and sensitive detection of biomarkers in various body fluids.

Applications

Unspecified application

Species

Unspecified reactive species

Zewei Lian,Jimei Chi,Xu Yang,Lijun Cheng,Daixi Xie,Zhiyu Tan,Sisi Chen,Yang Yun,Yisilamu Yibulayimu,Wei Wu,Yanlin Song,Meng Su

Basic research in cardiology 119:1029-1043 PubMed39120717

2024

Proprioceptors of the human pericardium.

Applications

Unspecified application

Species

Unspecified reactive species

Lea M Piermaier,Svenja Caspers,Christina Herold,Michael Wolf-Vollenbröker,Patrick Brzoska,Eric Bechler,Timm J Filler

Journal of cell science 136: PubMed36744428

2023

LRRK1 functions as a scaffold for PTP1B-mediated EGFR sorting into ILVs at the ER-endosome contact site.

Applications

Unspecified application

Species

Unspecified reactive species

Hiroshi Hanafusa,Keitaro Fujita,Misa Kamio,Shiori Iida,Yasushi Tamura,Naoki Hisamoto,Kunihiro Matsumoto

Pain reports 7:e990 PubMed35295965

2022

Transient hypoalgesia after COVID-19 infection.

Applications

Unspecified application

Species

Unspecified reactive species

Juliane Becker,Aikaterini Papagianni,Eva Herrmann,Frank Nöller,Claudia Sommer,Heike L Rittner

Surgical and radiologic anatomy : SRA 42:127-136 PubMed31493007

2019

On the importance of the innervation of the human cervical longitudinal ligaments at vertebral level.

Applications

Unspecified application

Species

Unspecified reactive species

Tina Stegmann,Hanno Steinke,Philipp Pieroh,Faramarz Dehghani,Anna Völker,Mathias Jakob Groll,Thomas Wolfskämpf,Michael Werner,Julia Kollan,Andreas Hinz,Mario Leimert
View all publications
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代替製品

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組合せ製品

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Secondary Antibodies

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Primary Antibodies

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Primary Antibodies

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