Anti-CEBP Beta 抗体 [1H7] (ab15050)
Key features and details
- Mouse monoclonal [1H7] to CEBP Beta
- Suitable for: ICC/IF, WB
- Reacts with: Mouse
- Isotype: IgG
製品の概要
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製品名
Anti-CEBP Beta antibody [1H7]
CEBP Beta 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [1H7] to CEBP Beta -
由来種
Mouse -
アプリケーション
適用あり: ICC/IF, WBmore details -
種交差性
交差種: Mouse -
免疫原
Recombinant full length LIP protein (Mouse)
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ポジティブ・コントロール
- ICC/IF: P388D1 cells WB: 3T3-L1 cell lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.1% BSA -
Concentration information loading...
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精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
1H7 -
アイソタイプ
IgG -
研究分野
関連製品
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ChIP Related Products
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab15050の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ICC/IF |
Use a concentration of 4 µg/ml. Fix with 4% paraformaldehyde.
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WB |
Use a concentration of 1 µg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 35,38,20 kDa).
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特記事項 |
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ICC/IF
Use a concentration of 4 µg/ml. Fix with 4% paraformaldehyde. |
WB
Use a concentration of 1 µg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 35,38,20 kDa). |
ターゲット情報
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機能
Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. -
組織特異性
Expressed at low levels in the lung, kidney and spleen. -
配列類似性
Belongs to the bZIP family. C/EBP subfamily.
Contains 1 bZIP domain. -
ドメイン
the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. -
翻訳後修飾
Sumoylated by polymeric chains of SUMO2 or SUMO3. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 12608 Mouse
- SwissProt: P28033 Mouse
- Unigene: 439656 Mouse
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別名
- AGP/EBP antibody
- C EBP beta antibody
- C/EBP beta antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (17)
ab15050 は 17 報の論文で使用されています。
- Dai Y et al. The Mechanism of Oxymatrine Targeting miR-27a-3p/PPAR-γ Signaling Pathway through m6A Modification to Regulate the Influence on Hemangioma Stem Cells on Propranolol Resistance. Cancers (Basel) 15:N/A (2023). PubMed: 37958388
- Liu Y et al. TET2 is recruited by CREB to promote Cebpb, Cebpa, and Pparg transcription by facilitating hydroxymethylation during adipocyte differentiation. iScience 26:108312 (2023). PubMed: 38026190
- Liu M et al. PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen. J Exp Med 219:N/A (2022). PubMed: 35266960
- Zhu Q et al. Protein arginine methyltransferase PRMT1 promotes adipogenesis by modulating transcription factors C/EBPβ and PPARγ. J Biol Chem 298:102309 (2022). PubMed: 35921899
- Sanmarco LM et al. Identification of environmental factors that promote intestinal inflammation. Nature 611:801-809 (2022). PubMed: 36266581