Anti-CDK1 抗体 [Y100.4] (ab5467)
Key features and details
- Mouse monoclonal [Y100.4] to CDK1
- Suitable for: WB
- Reacts with: Schizosaccharomyces pombe
- Isotype: IgG2b
製品の概要
-
製品名
Anti-CDK1 antibody [Y100.4]
CDK1 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [Y100.4] to CDK1 -
由来種
Mouse -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Schizosaccharomyces pombe -
免疫原
Synthetic C-terminal peptide:
AKRALQQNYLRDFH
(Schizosaccharomyces pombe) -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Constituent: PBS -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
Y100.4 -
ミエローマ
Sp2 -
アイソタイプ
IgG2b -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab5467の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use at an assay dependent concentration.
|
| 特記事項 |
|---|
|
WB
Use at an assay dependent concentration. |
ターゲット情報
-
機能
Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. -
組織特異性
Isoform 2 is found in breast cancer tissues. -
配列類似性
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain. -
細胞内局在
Nucleus. - Information by UniProt
-
参照データベース
- SwissProt: P04551 Schizosaccharomyces pombe
-
製品の状態
CDK1 can be located to the Nucleus, cytoplasm and Mithocondria. It's cytoplasmic during interphase and reversibly translocated from cytoplasm to the nucleus when phosphorilated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage. -
別名
- Cdc 2 antibody
- Cdc2 antibody
- CDC28A antibody
see all
データシートおよび資料
-
Datasheet download
参考文献 (24)
ab5467 は 24 報の論文で使用されています。
- Andric V et al. A scaffold lncRNA shapes the mitosis to meiosis switch. Nat Commun 12:770 (2021). PubMed: 33536434
- Pickering M et al. The fission yeast S-phase cyclin Cig2 can drive mitosis. Genetics 217:1-12 (2021). PubMed: 33683349
- Mennie AK et al. LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast. Nat Commun 9:586 (2018). WB ; Schizosaccharomyces pombe . PubMed: 29422503
- Fletcher J et al. Nutrient Limitation Inactivates Mrc1-to-Cds1 Checkpoint Signalling in Schizosaccharomyces pombe. Cells 7:N/A (2018). PubMed: 29473861
- Caspari T et al. The drinking water contaminant dibromoacetonitrile delays G1-S transition and suppresses Chk1 activation at broken replication forks. Sci Rep 7:12730 (2017). PubMed: 28986587
