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AB108950

Anti-CD63 抗体 [AD1]

Anti-CD63 antibody [AD1]

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(38 Publications)

Mouse Monoclonal CD63 antibody. Suitable for Flow Cyt and reacts with Rat samples. Cited in 38 publications. Immunogen corresponding to Cell preparation containing Cd63 protein.

別名を表示する

CD63, CD63 antigen, Mast cell antigen AD1, Cd63

1 Images
Flow Cytometry - Anti-CD63 antibody [AD1] (AB108950)
  • Flow Cyt

Unknown

Flow Cytometry - Anti-CD63 antibody [AD1] (AB108950)

Rat peripheral blood platelets stained with AlexaFluor®488 conjugated version of ab108950.

関連する標識済み抗体及び組成の異なる製品 (1)

  • 519 FITC

    FITC Anti-CD63 antibody [AD1]

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

AD1

アイソタイプ

IgG1

キャリアフリー

No

交差種

Rat

アプリケーション

Flow Cyt

applications

免疫原

Cell preparation containing Cd63 protein. The exact immunogen used to generate this antibody is proprietary information.

P28648

特異性

Rat CD63 is expressed on mast cells, and studies using clone AD1, have shown that it is located near to FcER1, and that clone AD1 partially inhibits IgE-mediated histamine release

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代替製品

Primary Antibodies

AB68418

Anti-CD63 antibody

KO Validated

Western blot - Anti-CD63 antibody (AB68418)

  • 5
  • 1
Primary Antibodies

AB233056

Alexa Fluor® 647 Anti-CD63 antibody [EPR21151]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-CD63 antibody [EPR21151] (AB233056)

  • 0
  • 0
Primary Antibodies

AB134045

Anti-CD63 antibody [EPR5702] - Late Endosome Marker

20ul selling size|RabMAb|Recombinant|KO Validated|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD63 antibody [EPR5702] - Late Endosome Marker (AB134045)

  • 3
  • 6
Primary Antibodies

AB215821

Anti-CD63 antibody [EPR5702] - BSA and Azide free

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD63 antibody [EPR5702] - BSA and Azide free (AB215821)

  • 0
  • 0
Primary Antibodies

AB227892

Anti-CD63 antibody [EPR21151] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-CD63 antibody [EPR21151] - BSA and Azide free (AB227892)

  • 0
  • 0
Primary Antibodies

AB233055

Alexa Fluor® 488 Anti-CD63 antibody [EPR21151]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 488 Anti-CD63 antibody [EPR21151] (AB233055)

  • 0
  • 0
Primary Antibodies

AB217345

Anti-CD63 antibody [EPR21151]

RabMAb|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-CD63 antibody [EPR21151] (AB217345)

  • 4
  • 5

組合せ製品

Assay Kits

AB275099

Human CD63 ELISA Kit

Recombinant|SimpleStep

ELISA - Human CD63 ELISA Kit (AB275099)

  • 0
  • 0
Primary Antibodies

AB125011

Anti-TSG101 antibody [EPR7130(B)]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry - Anti-TSG101 antibody [EPR7130(B)] (AB125011)

  • 4
  • 10
Primary Antibodies

AB236630

Anti-CD9 antibody [EPR23105-121]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD9 antibody [EPR23105-121] (AB236630)

  • 5
  • 4
Primary Antibodies

AB22595

Anti-Calnexin antibody - ER Marker

Lab Essentials|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Calnexin antibody - ER Marker (AB22595)

  • 5
  • 28
Primary Antibodies

AB79559

Anti-CD81 antibody [M38]

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD81 antibody [M38] (AB79559)

  • 4
  • 2
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/10 - 1/200", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
精製に関する特記事項
Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant.
バッファー組成
Preservative: 0.09% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD63 is a protein commonly known as LAMP-3 a member of the tetraspanin family with a molecular weight of approximately 25-65 kDa depending on post-translational modifications such as glycosylation. It resides mainly on the membrane of intracellular vesicles such as lysosomes and platelets. CD63 also appears on the surface of activated cells particularly in immune cells. Researchers often use CD63 as a marker in assays including CD63 western blot techniques due to its distinct expression patterns.
Biological function summary

CD63 participates in various cellular processes including membrane trafficking cell adhesion and signal transduction. It associates with integrins and other tetraspanins forming complexes that influence cellular adhesion and migration. Through its role in exosome formation CD63 contributes significantly to intercellular communication by facilitating the transfer of proteins lipids and RNA between cells.

Pathways

CD63 plays a role in pathways linked to cell proliferation and migration and immune response regulation. Within the integrin-mediated signaling pathway CD63 interacts with proteins such as integrins to promote cell adhesion and migration. CD63 also links to vesicle trafficking pathways collaborating with proteins involved in exocytosis and endocytosis which affect cell membrane restructuring and intracellular transport.

CD63 shows connections with cancer and immune system disorders. Its role in promoting cell adhesion and migration links it with cancer metastasis including melanoma and breast cancer where CD63 expression levels often rise. Additionally CD63 associates with allergic reactions due to its involvement in histamine release where it impacts immune proteins like FcεRI which participate in allergy pathogenesis.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli (By similarity).
See full target information Cd63
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文献 (38)

Recent publications for all applications. Explore the full list and refine your search

Journal of orthopaedic translation 53:187-205 PubMed40678612

2025

PPARγ controls ESCRT-dependent fibroblast-like synoviocyte exosome biogenesis and alleviates chondrocyte osteoarthritis mediated by exosomal ANXA1.

Applications

Unspecified application

Species

Unspecified reactive species

Shuangshuo Jia,Yue Yang,Jiabao Liu,Ziyuan Wang,Lunhao Bai

Molecular medicine reports 31: PubMed39540371

2024

Dental pulp stem cell‑derived extracellular vesicles loaded with hydrogels promote osteogenesis in rats with alveolar bone defects.

Applications

Unspecified application

Species

Unspecified reactive species

Xin He,Xiao-Yang Chu,Xu Chen,Yu-Lan Xiang,Ze-Lu Li,Chun-Yan Gao,Ying-Yi Luan,Kai Yang,Dong-Liang Zhang

Neural regeneration research 20:277-290 PubMed38767492

2024

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells.

Applications

Unspecified application

Species

Unspecified reactive species

Meng Cong,Jing-Jing Hu,Yan Yu,Xiao-Li Li,Xiao-Ting Sun,Li-Ting Wang,Xia Wu,Ling-Jie Zhu,Xiao-Jia Yang,Qian-Ru He,Fei Ding,Hai-Yan Shi

Skeletal muscle 13:6 PubMed36895061

2023

Extracellular vesicle distribution and localization in skeletal muscle at rest and following disuse atrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Ahmed Ismaeel,Douglas W Van Pelt,Zachary R Hettinger,Xu Fu,Christopher I Richards,Timothy A Butterfield,Jonathan J Petrocelli,Ivan J Vechetti,Amy L Confides,Micah J Drummond,Esther E Dupont-Versteegden

iScience 25:105141 PubMed36204278

2022

Schwann cells-derived exosomal miR-21 participates in high glucose regulation of neurite outgrowth.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Pu Liu,Ming-Yue Tian,Yi-Duo Yang,Han Li,Tian-Tian Zhao,Jing Zhu,Fang-Fang Mou,Guo-Hong Cui,Hai-Dong Guo,Shui-Jin Shao

Cell biology international 46:2028-2040 PubMed36098338

2022

Exosomes to control glioblastoma multiforme: Investigating the effects of mesenchymal stem cell-derived exosomes on C6 cells in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Houman Parsaei,Mir Javad Moosavifar,Mina Eftekharzadeh,Reihaneh Ramezani,Mahmood Barati,Soheil Mirzaei,Maliheh Nobakht

BioMed research international 2022:8537959 PubMed36119932

2022

VEGFA-Enriched Exosomes from Tendon-Derived Stem Cells Facilitate Tenocyte Differentiation, Migration, and Transition to a Fibroblastic Phenotype.

Applications

Unspecified application

Species

Unspecified reactive species

Zhaowen Xue,Zihang Chen,Tingting Wu,Riwang Li,Chao Chen,Junting Liu,Huige Hou,Xiaofei Zheng,Huajun Wang

International heart journal 63:591-601 PubMed35650159

2022

CircSLC8A1 Exacerbates Hypoxia-Induced Myocardial Injury via Interacting with MiR-214-5p to Upregulate TEAD1 Expression.

Applications

Unspecified application

Species

Unspecified reactive species

Zhong Lan,Tao Wang,Lihong Zhang,Zhizhong Jiang,Xiaoming Zou

Oxidative medicine and cellular longevity 2022:7530102 PubMed35132352

2022

Exosome-Mediated miR-21 Was Involved in the Promotion of Structural and Functional Recovery Effect Produced by Electroacupuncture in Sciatic Nerve Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Pu Liu,Yi-Duo Yang,Fang-Fang Mou,Jing Zhu,Han Li,Tian-Tian Zhao,Yue Zhao,Shui-Jin Shao,Guo-Hong Cui,Hai-Dong Guo

Journal of cellular and molecular medicine 26:1486-1500 PubMed35088943

2022

Exosomes as a messager to regulate the crosstalk between macrophages and cardiomyocytes under hypoxia conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Zenglei Zhang,Yanyan Xu,Chang Cao,Bo Wang,Jiacheng Guo,Zhen Qin,Yongzheng Lu,Jianchao Zhang,Li Zhang,Wei Wang,Jinying Zhang,Junnan Tang
View all publications
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