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AB204949

Anti-CD6/T12 抗体 [5A10A2]

Anti-CD6/T12 antibody [5A10A2]

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(1 Publication)

Mouse Monoclonal CD6/T12 antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human T-cell differentiation antigen CD6 aa 1-200.

別名を表示する

CD6, T-cell differentiation antigen CD6, T12, TP120

3 Images
Flow Cytometry - Anti-CD6/T12 antibody [5A10A2] (AB204949)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-CD6/T12 antibody [5A10A2] (AB204949)

Flow cytometric analysis of Jurkat cells labeling CD6/T12 with ab204949 at 1/200 dilution (green) compared with a negative control (red).

Western blot - Anti-CD6/T12 antibody [5A10A2] (AB204949)
  • WB

Supplier Data

Western blot - Anti-CD6/T12 antibody [5A10A2] (AB204949)

All lanes:

Western blot - Anti-CD6/T12 antibody [5A10A2] (ab204949) at 1/500 dilution

Lane 1:

HEK293 cell lysate

Lane 2:

CD6/T12 (aa 18-199)-hIgGFc transfected HEK293 cell lysate

Predicted band size: 72 kDa

false

Western blot - Anti-CD6/T12 antibody [5A10A2] (AB204949)
  • WB

Supplier Data

Western blot - Anti-CD6/T12 antibody [5A10A2] (AB204949)

All lanes:

Western blot - Anti-CD6/T12 antibody [5A10A2] (ab204949) at 1/500 dilution

All lanes:

Human CD6/T12 (aa: 18-199) recombinant protein

Predicted band size: 72 kDa

false

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

5A10A2

アイソタイプ

IgG2b

キャリアフリー

No

交差種

Human

アプリケーション

WB, Flow Cyt

applications

免疫原

Recombinant Fragment Protein within Human T-cell differentiation antigen CD6 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

P30203

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/200 - 1/400", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
精製に関する特記事項
Purified from tissue culture supernatant.
バッファー組成
Preservative: 0.05% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD6 also known as T12 is a glycoprotein expressed on T cells and some subsets of B cells. The protein has a molecular mass of approximately 105-130 kDa. CD6 is primarily located on the surface of thymocytes mature T lymphocytes and on some B cell lines. It plays an important role in the immunological synapse serving as a receptor that aids in cell-to-cell communication during immune responses. The CD6 protein is also detectable in immune tissues including the spleen and lymph nodes.
Biological function summary

CD6 functions involve T cell maturation and proliferation. The protein is part of the lymphocyte activation complex contributing to the modulation of T cell receptor (TCR) signaling. It interacts with other cell surface proteins such as CD3 and CD28 to influence the response of T cells to antigens. CD6 potentially modulates the threshold for T cell activation favoring the adjustment of immune responses to various antigens.

Pathways

CD6 participates in the signaling pathways that regulate adaptive immune responses. It is involved in the T cell receptor (TCR) signaling pathway essential for T cell activation and differentiation. CD6 interacts with proteins like LCK and ZAP-70 which are pivotal for the TCR signaling cascade. Additionally CD6's role in immune synapse formation connects it to the modulation of cytokine production and immune cell communication.

CD6 associates with autoimmune diseases and multiple sclerosis. The protein's involvement in T cell activation and immune regulation makes it a candidate for studies targeting autoimmune pathologies. Autoimmune disorders such as rheumatoid arthritis have shown links with CD6's activity as its deregulation can lead to inappropriate immune responses. Additionally CD6's interaction with proteins like CD166 has implications in the pathogenesis of these disorders indicating a potential target for therapeutic interventions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed : 15048703, PubMed : 15294938, PubMed : 16352806, PubMed : 16914752, PubMed : 24584089, PubMed : 24945728). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed : 24584089). Functions as a costimulatory molecule; promotes T-cell activation and proliferation (PubMed : 15294938, PubMed : 16352806, PubMed : 16914752). Contributes to the formation and maturation of the immunological synapse (PubMed : 15294938, PubMed : 16352806). Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed : 17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed : 17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed : 17601777).
See full target information T-cell differentiation antigen CD6
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of cancer research 13:3898-3920 PubMed37818072

2023

Bioinformatics analysis and experimental validation identified HMGA2/microRNA-200c-3p/LSAMP/Wnt axis as an immunological factor of patients with colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xi Xu,Chaoju Gong,Yunfeng Wang,Zhidong Yin,Xiaogang Wang,Yanyan Hu,Zejun Fang
View all publications
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代替製品

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AB193341

Anti-CD6/T12 antibody [3F7B5]

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  • 0
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Primary Antibodies

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Primary Antibodies

AB109217

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  • 0
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Primary Antibodies

AB213007

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD6/T12 antibody [3F7B5] - BSA and Azide free (AB213007)

  • 0
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Primary Antibodies

AB199008

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD6/T12 antibody [C6/372 + 3F7B5] (AB199008)

  • 0
  • 0
Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD6/T12 antibody [EPR4056] (AB109218)

  • 0
  • 0

組合せ製品

Assay Kits

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Human CD6/T12 ELISA Kit

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Secondary Antibodies

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Primary Antibodies

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Primary Antibodies

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Anti-GSK3 beta antibody [Y174]

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