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AB33273

Anti-CD57 抗体 [TB01]

Anti-CD57 antibody [TB01]

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(2 Publications)

Mouse Monoclonal CD57 antibody. Suitable for Flow Cyt, IHC-P, IHC-Fr and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Cell preparation containing CD57 protein.

別名を表示する

HKN1, LEU7

関連する標識済み抗体及び組成の異なる製品 (3)

  • 519 FITC

    FITC Anti-CD57 antibody [TB01]

  • 660 APC

    APC Anti-CD57 antibody [TB01]

  • 578 PE

    PE Anti-CD57 antibody [TB01]

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

TB01

アイソタイプ

IgM

キャリアフリー

No

交差種

Human

アプリケーション

IHC-Fr, Flow Cyt, IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "1/50 - 1/100", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/mouse-igm-b11-7-isotype-control-ab91545'>ab91545</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.</p><p>Use 10μl of the suggested working dilution to label 10<sup>6</sup> cells in 100μl.</p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/10 - 1/50", "IHCP-species-notes": "<p>This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections but sodium citrate buffer may enhance staining.</p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "1/10 - 1/100", "IHCFr-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Ion exchange chromatography
バッファー組成
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD57 also known as HNK-1 is a glycoprotein with a molecular weight of approximately 110 to 150 kDa. It is a marker expressed on the surface of natural killer (NK) cells T lymphocytes and some subsets of CD8+ T cells. Besides you can find this marker in neural tissue. As a surface marker CD57 is used in human immunohistochemistry (IHC) studies to identify cell populations in immune responses and has significant utility in the characterization of lymphocyte subsets.
Biological function summary

CD57 plays a role in immune regulation and cell-mediated cytotoxicity. CD57+ cells which are often mature or post-activation states in NK cells and T lymphocytes are less proliferative but have enhanced cytotoxic abilities. These cells contribute to the immune surveillance against viral infections and tumor cells. CD57 does not belong to any well-known protein complexes but can cooperate with other surface markers to modulate immune functions.

Pathways

CD57+ cell populations participate in the immune system pathways related to cell-mediated immunity and cytotoxic response. The presence of CD57 is often associated with the downregulation of proliferative pathways and the enhancement of cytotoxic pathways. It shows functional overlap with proteins such as CD16 and NKG2D which also play roles in mediating the cytotoxic activity of NK cells.

CD57 is connected to chronic infections and certain autoimmune conditions. In chronic viral infections like HIV CD57+ T cells show a state of replicative senescence where their persistent expression links to disease progression. In autoimmune disorders like rheumatoid arthritis CD57+ T cells are found in the inflamed tissues. This protein works alongside CD8 in conditions of immune dysfunction providing insights into immune status and disease activity.

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

ターゲットの情報

See full target information CD57

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

British journal of cancer 131:258-270 PubMed38834745

2024

CD57 defines a novel cancer stem cell that drive invasion of diffuse pediatric-type high grade gliomas.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Qi,Yuchen Du,Yulun Huang,Mari Kogiso,Huiyuan Zhang,Sophie Xiao,Aalaa Abdallah,Milagros Suarez,Long Niu,Zhi-Gang Liu,Holly Lindsay,Frank K Braun,Clifford Stephen,Peter J Davies,Wan Yee Teo,Adesina Adenkunle,Patricia Baxter,Jack Mf Su,Xiao-Nan Li

Journal of leukocyte biology 76:667-75 PubMed15178706

2004

Unique phenotype of human uterine NK cells and their regulation by endogenous TGF-beta.

Applications

Unspecified application

Species

Unspecified reactive species

Mikael Eriksson,Sarah K Meadows,Charles R Wira,Charles L Sentman
View all publications

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