Anti-CD55 抗体 [67] (ab20145)
Key features and details
- Mouse monoclonal [67] to CD55
- Suitable for: IHC-Fr
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-CD55 antibody [67]
CD55 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [67] to CD55 -
由来種
Mouse -
アプリケーション
適用あり: IHC-Frmore details -
種交差性
交差種: Human -
免疫原
Tissue, cells or virus corresponding to CD55. Fibronectin purified monocytes.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.02% Sodium azide
Constituent: 99.98% PBS -
Concentration information loading... -
精製度
Protein A/G purified -
ポリ/モノ
モノクローナル -
クローン名
67 -
ミエローマ
Sp2/0 -
アイソタイプ
IgG1 -
軽鎖の種類
unknown -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab20145の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-Fr |
Use at an assay dependent concentration.
Fix with acetone. |
| 特記事項 |
|---|
|
IHC-Fr
Use at an assay dependent concentration. Fix with acetone. |
ターゲット情報
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機能
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. -
組織特異性
Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix. -
配列類似性
Belongs to the receptors of complement activation (RCA) family.
Contains 4 Sushi (CCP/SCR) domains. -
ドメイン
The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3. -
翻訳後修飾
The Ser/Thr-rich domain is heavily O-glycosylated. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 1604 Human
- Omim: 125240 Human
- SwissProt: P08174 Human
- Unigene: 126517 Human
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別名
- CD 55 antibody
- CD55 antibody
- CD55 antigen antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (6)
ab20145 は 6 報の論文で使用されています。
- Bahia El Idrissi N et al. Complement activation at the motor end-plates in amyotrophic lateral sclerosis. J Neuroinflammation 13:72 (2016). PubMed: 27056040
- Natsume A et al. Engineered anti-CD20 antibodies with enhanced complement-activating capacity mediate potent anti-lymphoma activity. Cancer Sci 100:2411-8 (2009). PubMed: 19758394
- Kamada K et al. Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720. Pathol Int 59:382-9 (2009). IHC-Fr ; Human . PubMed: 19490468
- Franchi A et al. Expression of immunomodulatory genes, their protein products and specific ligands/receptors during the window of implantation in the human endometrium. Mol Hum Reprod 14:413-21 (2008). PubMed: 18524812
- Leitinger B & Hogg N The involvement of lipid rafts in the regulation of integrin function. J Cell Sci 115:963-72 (2002). PubMed: 11870215
- Palmer DG et al. Features of synovial membrane identified with monoclonal antibodies. Clin Exp Immunol 59:529-38 (1985). PubMed: 3886218