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AB20145

Anti-CD55 抗体 [67]

Anti-CD55 antibody [67]

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(6 Publications)

Mouse Monoclonal DAF antibody. Suitable for IHC-Fr and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Cell preparation containing CD55 protein.

別名を表示する

CD55, CR, DAF, Complement decay-accelerating factor

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

67

アイソタイプ

IgG1

軽鎖のタイプ

unknown

キャリアフリー

No

交差種

Human

アプリケーション

IHC-Fr

applications

免疫原

Cell preparation containing CD55 protein. The exact immunogen used to generate this antibody is proprietary information.

P08174

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p>Fix with acetone.</p>" } } }
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下記製品にもご興味をお持ちいただけるかもしれません:

AB256405

Human DAF ELISA Kit (CD55)

0

0 Reviews

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こちらの製品も推奨する理由

この製品は、同様の実験や関連する研究で広く使用されていることから推奨させていただいております。

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A/G
バッファー組成
Preservative: 0.02% Sodium azide Constituents: 99.98% PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD55 also known as Decay-Accelerating Factor (DAF) is a glycoprotein that regulates the complement cascade. This protein typically weighs around 70 kDa. It is expressed in many cells including epithelial and endothelial cells and is often present on the surface of blood cells. CD55 plays an important role in protecting cells against lysis by inhibiting the formation and stability of C3 and C5 convertases which ultimately prevent cell destruction by the complement system.
Biological function summary

CD55 helps maintain immune homeostasis by preventing the complement-mediated damage to host tissues. It functions as a member of the regulators of complement activation (RCA) family. While not necessarily part of a larger protein complex its function is related to other regulatory proteins such as CD46 and CD59 which cooperate to regulate complement activity. The DAF protein's immunology function is instrumental in ensuring that self-cells are not inadvertently attacked by the body's immune system.

Pathways

CD55 significantly impacts the complement pathway which is a central component of the innate immune system. It directly interacts with complement components C3 and C5 accelerating their decay and disassembly. Through this pathway CD55 has a working relationship with other complement regulatory proteins like Factor H which also aids in controlling complement activation on the cell surface.

A dysfunctional CD55 can relate to conditions such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). In PNH the absence or insufficiency of CD55 (and CD59) on red blood cells leads to complement-mediated lysis causing hemolytic anemia. In aHUS impaired regulation of the complement system including abnormalities in CD55 function exacerbates symptoms. CD55's role is therefore important in preventing these complement-related disorders and preserving cellular integrity in the human body.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed : 7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed : 28657829).. (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5.. (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable).. (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21.
See full target information CD55
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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

Journal of neuroinflammation 13:72 PubMed27056040

2016

Complement activation at the motor end-plates in amyotrophic lateral sclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

Nawal Bahia El Idrissi,Sanne Bosch,Valeria Ramaglia,Eleonora Aronica,Frank Baas,Dirk Troost

Cancer science 100:2411-8 PubMed19758394

2009

Engineered anti-CD20 antibodies with enhanced complement-activating capacity mediate potent anti-lymphoma activity.

Applications

Unspecified application

Species

Unspecified reactive species

Akito Natsume,Yukiko Shimizu-Yokoyama,Mitsuo Satoh,Kenya Shitara,Rinpei Niwa

Pathology international 59:382-9 PubMed19490468

2009

Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720.

Applications

IHC-Fr

Species

Human

Kazuo Kamada,Norimasa Arita,Takahito Tsubaki,Nobuo Takubo,Takahiro Fujino,Yoshiko Soga,Tatsuhiko Miyazaki,Haruyasu Yamamoto,Masato Nose

Molecular human reproduction 14:413-21 PubMed18524812

2008

Expression of immunomodulatory genes, their protein products and specific ligands/receptors during the window of implantation in the human endometrium.

Applications

Unspecified application

Species

Unspecified reactive species

Anahi Franchi,Jessica Zaret,Xiaomei Zhang,Silvina Bocca,Sergio Oehninger

Journal of cell science 115:963-72 PubMed11870215

2002

The involvement of lipid rafts in the regulation of integrin function.

Applications

Unspecified application

Species

Unspecified reactive species

Birgit Leitinger,Nancy Hogg

Clinical and experimental immunology 59:529-38 PubMed3886218

1985

Features of synovial membrane identified with monoclonal antibodies.

Applications

Unspecified application

Species

Unspecified reactive species

D G Palmer,Y Selvendran,C Allen,P A Revell,N Hogg
View all publications
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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